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• W3021971857 abstract "Acetylcholine (Ach) is discovered in ergot-containing plant material and when applied to peripheral tissues, ACh has the same effect as that of the stimulation of parasympathetic nerves. ACh serves as a neurotransmitter at peripheral ganglia and as a mediator of the parasympathetic actions of the autonomic nervous system. ACh is established as an early organic molecule that dominates by its presence in the nervous system. It is also synthesized in bacteria, fungi, protozoa, and plants. Perhaps as a result of ACh's early appearance during evolution, a number of toxins that interfere with the action of ACh at the neuromuscular junction (NMJ) that are used to advantage by predators have been identified. ACh is also found in non-neural tissues such as epithelial cells, cornea, and placenta, although the physiological significance remains unclear. A specific vesicular ACh transporter (VAChT) mediates the transfer of ACh from the cytoplasm into synaptic vesicles. VAChT is an antiporter that couples ACh entry into the vesicle with proton efflux, the same mechanism used for the accumu­lation of other biogenic amine neurotransmitters. In addition to its pivotal role in the study of chemical trans­mission, ACh is instrumental in the pharmacological clas­sification of receptors." @default.
• W3021971857 created "2020-05-13" @default.
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• W3021971857 date "2012-01-01" @default.
• W3021971857 modified "2023-10-17" @default.
• W3021971857 title "Acetylcholine" @default.
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• W3021971857 doi "https://doi.org/10.1016/b978-0-12-374947-5.00013-4" @default.
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