FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021982504> ?p ?o ?g. }

• W3021982504 abstract "Atherosclerosis is caused by chronic inflammation associated with the adhesion of neutrophils and endothelial cells (ECs) that is mediated by their respective cellular adhesive molecules to stiffened blood vessel walls. However, the stiffness dependence of calcium flux on neutrophils remains unclear yet. Here, the effect of substrate stiffness by ECs on neutrophils' calcium spike was quantified when the individual neutrophils that adhered to the human umbilical vascular endothelial cell (HUVEC) monolayer were pre-placed onto a stiffness-varied polyacrylamide substrate (5 or 34.88 kPa) or glass surface. Our data indicated that E-/P-selectins and intercellular adhesion molecule 1 (ICAM-1) on HUVECs and β2-integrins, P-selectin glycoprotein ligand 1 (PSGL-1), and CD44s on neutrophils were all involved in mediating neutrophil calcium spike in a stiffness-dependent manner, in which the increase in substrate stiffness enhanced the calcium intensity and the oscillation frequency (spike number). Such stiffness-dependent calcium response is associated with the induced selectin related to β2-integrin activation through the Syk/Src signaling pathway, and F-actin/myosin II are also involved in this. Moreover, tension-activated calcium ion channels displayed critical roles in initiating stiffness-dependent calcium spike. These results provide an insight into understanding how the stiffening of vascular walls could regulate the calcium flux of adhered neutrophils, and thus the immune responses in atherosclerosis." @default.
• W3021982504 created "2020-05-13" @default.
• W3021982504 creator A5017334286 @default.
• W3021982504 creator A5036832196 @default.
• W3021982504 creator A5053746291 @default.
• W3021982504 creator A5054672150 @default.
• W3021982504 creator A5073236451 @default.
• W3021982504 date "2019-03-01" @default.
• W3021982504 modified "2023-10-15" @default.
• W3021982504 title "Mechanical features of endothelium regulate cell adhesive molecule-induced calcium response in neutrophils" @default.
• W3021982504 cites W1600560134 @default.
• W3021982504 cites W1625630534 @default.
• W3021982504 cites W1841686436 @default.
• W3021982504 cites W1967765380 @default.
• W3021982504 cites W1968510478 @default.
• W3021982504 cites W1991340785 @default.
• W3021982504 cites W1995535951 @default.
• W3021982504 cites W2000563705 @default.
• W3021982504 cites W2006047046 @default.
• W3021982504 cites W2008415358 @default.
• W3021982504 cites W2023198480 @default.
• W3021982504 cites W2027414724 @default.
• W3021982504 cites W2032334748 @default.
• W3021982504 cites W2038007769 @default.
• W3021982504 cites W2051185006 @default.
• W3021982504 cites W2052766715 @default.
• W3021982504 cites W2055940657 @default.
• W3021982504 cites W2058268269 @default.
• W3021982504 cites W2058738554 @default.
• W3021982504 cites W2060530584 @default.
• W3021982504 cites W2061357138 @default.
• W3021982504 cites W2064341334 @default.
• W3021982504 cites W2066312918 @default.
• W3021982504 cites W2066963386 @default.
• W3021982504 cites W2067776924 @default.
• W3021982504 cites W2079943399 @default.
• W3021982504 cites W2087850490 @default.
• W3021982504 cites W2089325024 @default.
• W3021982504 cites W2089963361 @default.
• W3021982504 cites W2094629035 @default.
• W3021982504 cites W2104418998 @default.
• W3021982504 cites W2106208034 @default.
• W3021982504 cites W2110375403 @default.
• W3021982504 cites W2112272521 @default.
• W3021982504 cites W2120011621 @default.
• W3021982504 cites W2122131535 @default.
• W3021982504 cites W2125843274 @default.
• W3021982504 cites W2128445597 @default.
• W3021982504 cites W2128793357 @default.
• W3021982504 cites W2129496249 @default.
• W3021982504 cites W2133059825 @default.
• W3021982504 cites W2137347544 @default.
• W3021982504 cites W2146455279 @default.
• W3021982504 cites W2148328620 @default.
• W3021982504 cites W2156413973 @default.
• W3021982504 cites W2167243609 @default.
• W3021982504 cites W2170389449 @default.
• W3021982504 cites W2193921588 @default.
• W3021982504 cites W2268475842 @default.
• W3021982504 cites W2282745969 @default.
• W3021982504 cites W2510061659 @default.
• W3021982504 cites W2528023612 @default.
• W3021982504 cites W2736658962 @default.
• W3021982504 cites W2749596444 @default.
• W3021982504 cites W2750779169 @default.
• W3021982504 cites W277210135 @default.
• W3021982504 cites W4211242914 @default.
• W3021982504 doi "https://doi.org/10.1063/1.5045115" @default.
• W3021982504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6481737" @default.
• W3021982504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31069337" @default.
• W3021982504 hasPublicationYear "2019" @default.
• W3021982504 type Work @default.
• W3021982504 sameAs 3021982504 @default.
• W3021982504 citedByCount "12" @default.
• W3021982504 countsByYear W30219825042019 @default.
• W3021982504 countsByYear W30219825042020 @default.
• W3021982504 countsByYear W30219825042021 @default.
• W3021982504 countsByYear W30219825042022 @default.
• W3021982504 crossrefType "journal-article" @default.
• W3021982504 hasAuthorship W3021982504A5017334286 @default.
• W3021982504 hasAuthorship W3021982504A5036832196 @default.
• W3021982504 hasAuthorship W3021982504A5053746291 @default.
• W3021982504 hasAuthorship W3021982504A5054672150 @default.
• W3021982504 hasAuthorship W3021982504A5073236451 @default.
• W3021982504 hasBestOaLocation W30219825041 @default.
• W3021982504 hasConcept C12554922 @default.
• W3021982504 hasConcept C1491633281 @default.
• W3021982504 hasConcept C155619193 @default.
• W3021982504 hasConcept C16224149 @default.
• W3021982504 hasConcept C178790620 @default.
• W3021982504 hasConcept C181080969 @default.
• W3021982504 hasConcept C185592680 @default.
• W3021982504 hasConcept C195687474 @default.
• W3021982504 hasConcept C519063684 @default.
• W3021982504 hasConcept C55493867 @default.
• W3021982504 hasConcept C84416704 @default.
• W3021982504 hasConcept C85789140 @default.
• W3021982504 hasConcept C86803240 @default.
• W3021982504 hasConcept C95444343 @default.
• W3021982504 hasConceptScore W3021982504C12554922 @default.

• next