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• W3021983165 abstract "Abstract Recently, epidemiological studies have suggested that fluoride is a human developmental neurotoxicant that reduces measures of intelligence in children, placing it into the same category as toxic metals (lead, methylmercury, arsenic) and polychlorinated biphenyls. If true, this assessment would be highly relevant considering the widespread fluoridation of drinking water and the worldwide use of fluoride in oral hygiene products such as toothpaste. To gain a deeper understanding of these assertions, we reviewed the levels of human exposure, as well as results from animal experiments, particularly focusing on developmental toxicity, and the molecular mechanisms by which fluoride can cause adverse effects. Moreover, in vitro studies investigating fluoride in neuronal cells and precursor/stem cells were analyzed, and 23 epidemiological studies published since 2012 were considered. The results show that the margin of exposure (MoE) between no observed adverse effect levels (NOAELs) in animal studies and the current adequate intake (AI) of fluoride (50 µg/kg b.w./day) in humans ranges between 50 and 210, depending on the specific animal experiment used as reference. Even for unusually high fluoride exposure levels, an MoE of at least ten was obtained. Furthermore, concentrations of fluoride in human plasma are much lower than fluoride concentrations, causing effects in cell cultures. In contrast, 21 of 23 recent epidemiological studies report an association between high fluoride exposure and reduced intelligence. The discrepancy between experimental and epidemiological evidence may be reconciled with deficiencies inherent in most of these epidemiological studies on a putative association between fluoride and intelligence, especially with respect to adequate consideration of potential confounding factors, e.g., socioeconomic status, residence, breast feeding, low birth weight, maternal intelligence, and exposure to other neurotoxic chemicals. In conclusion, based on the totality of currently available scientific evidence, the present review does not support the presumption that fluoride should be assessed as a human developmental neurotoxicant at the current exposure levels in Europe." @default.
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• W3021983165 date "2020-05-01" @default.
• W3021983165 modified "2023-10-18" @default.
• W3021983165 title "Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses" @default.
• W3021983165 cites W1182588605 @default.
• W3021983165 cites W1505405752 @default.
• W3021983165 cites W1662143292 @default.
• W3021983165 cites W1852003237 @default.
• W3021983165 cites W1902193009 @default.
• W3021983165 cites W1964397519 @default.
• W3021983165 cites W1972037661 @default.
• W3021983165 cites W1974176290 @default.
• W3021983165 cites W1974361731 @default.
• W3021983165 cites W1980980444 @default.
• W3021983165 cites W1981329163 @default.
• W3021983165 cites W1985247208 @default.
• W3021983165 cites W1987399090 @default.
• W3021983165 cites W1993095801 @default.
• W3021983165 cites W1996334726 @default.
• W3021983165 cites W1998809922 @default.
• W3021983165 cites W1999686954 @default.
• W3021983165 cites W1999813969 @default.
• W3021983165 cites W1999888331 @default.
• W3021983165 cites W2000150984 @default.
• W3021983165 cites W2002246334 @default.
• W3021983165 cites W2003379656 @default.
• W3021983165 cites W2008041243 @default.
• W3021983165 cites W2010114210 @default.
• W3021983165 cites W2012399070 @default.
• W3021983165 cites W2017827400 @default.
• W3021983165 cites W2018832868 @default.
• W3021983165 cites W2022986216 @default.
• W3021983165 cites W2029533476 @default.
• W3021983165 cites W2032502770 @default.
• W3021983165 cites W2033810717 @default.
• W3021983165 cites W2035421028 @default.
• W3021983165 cites W2036387407 @default.
• W3021983165 cites W2036762936 @default.
• W3021983165 cites W2037888028 @default.
• W3021983165 cites W2043685736 @default.
• W3021983165 cites W2044865240 @default.
• W3021983165 cites W2047847309 @default.
• W3021983165 cites W2048652887 @default.
• W3021983165 cites W2048934444 @default.
• W3021983165 cites W2050032817 @default.
• W3021983165 cites W2052105313 @default.
• W3021983165 cites W2054962321 @default.
• W3021983165 cites W2064607595 @default.
• W3021983165 cites W2065028296 @default.
• W3021983165 cites W2065080530 @default.
• W3021983165 cites W2066271236 @default.
• W3021983165 cites W2068254130 @default.
• W3021983165 cites W2071991556 @default.
• W3021983165 cites W2072655043 @default.
• W3021983165 cites W2073913408 @default.
• W3021983165 cites W2078388509 @default.
• W3021983165 cites W2080885571 @default.
• W3021983165 cites W2086176489 @default.
• W3021983165 cites W2088338566 @default.
• W3021983165 cites W2089617988 @default.
• W3021983165 cites W2089988952 @default.
• W3021983165 cites W2090656509 @default.
• W3021983165 cites W2104270711 @default.
• W3021983165 cites W2105838456 @default.
• W3021983165 cites W2121672205 @default.
• W3021983165 cites W2121753427 @default.

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