Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021993914> ?p ?o ?g. }
- W3021993914 abstract "Abstract Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10 −15 ) and replication (adjusted OR = 2.93, P = 2.22 × 10 −3 ) that is more pronounced in females (adjusted OR = 6.81 and 3.19 and for discovery and replication). We observe an excess loss of heterozygosity in lung tumors among ATM L2307F allele carriers. L2307F is more frequent (4%) among Ashkenazi Jewish populations. We also observe an association in discovery (adjusted OR = 2.61, P = 7.98 × 10 −22 ) and replication datasets (adjusted OR = 1.55, P = 0.06) with a loss-of-function mutation, Q4X (rs150665432) of an uncharacterized gene, KIAA0930 . Our findings implicate germline genetic variants in ATM with lung cancer susceptibility and suggest KIAA0930 as a novel candidate gene for lung cancer risk." @default.
- W3021993914 created "2020-05-13" @default.
- W3021993914 creator A5000350877 @default.
- W3021993914 creator A5000702560 @default.
- W3021993914 creator A5000739842 @default.
- W3021993914 creator A5000877350 @default.
- W3021993914 creator A5001258652 @default.
- W3021993914 creator A5001535159 @default.
- W3021993914 creator A5001757617 @default.
- W3021993914 creator A5001857260 @default.
- W3021993914 creator A5001980972 @default.
- W3021993914 creator A5002376961 @default.
- W3021993914 creator A5002463978 @default.
- W3021993914 creator A5002857362 @default.
- W3021993914 creator A5003126557 @default.
- W3021993914 creator A5004384935 @default.
- W3021993914 creator A5004491112 @default.
- W3021993914 creator A5004669792 @default.
- W3021993914 creator A5005876352 @default.
- W3021993914 creator A5006114897 @default.
- W3021993914 creator A5007009847 @default.
- W3021993914 creator A5007160329 @default.
- W3021993914 creator A5008606431 @default.
- W3021993914 creator A5009454568 @default.
- W3021993914 creator A5010504061 @default.
- W3021993914 creator A5011467039 @default.
- W3021993914 creator A5011954023 @default.
- W3021993914 creator A5012210223 @default.
- W3021993914 creator A5012748795 @default.
- W3021993914 creator A5016405051 @default.
- W3021993914 creator A5016557698 @default.
- W3021993914 creator A5018076305 @default.
- W3021993914 creator A5019050324 @default.
- W3021993914 creator A5019329822 @default.
- W3021993914 creator A5020398489 @default.
- W3021993914 creator A5022511267 @default.
- W3021993914 creator A5022550644 @default.
- W3021993914 creator A5023531951 @default.
- W3021993914 creator A5024663234 @default.
- W3021993914 creator A5027061852 @default.
- W3021993914 creator A5028047746 @default.
- W3021993914 creator A5028111106 @default.
- W3021993914 creator A5028344545 @default.
- W3021993914 creator A5028712491 @default.
- W3021993914 creator A5028989565 @default.
- W3021993914 creator A5029703491 @default.
- W3021993914 creator A5029805571 @default.
- W3021993914 creator A5030064179 @default.
- W3021993914 creator A5030964262 @default.
- W3021993914 creator A5031124240 @default.
- W3021993914 creator A5031376185 @default.
- W3021993914 creator A5033421883 @default.
- W3021993914 creator A5034359692 @default.
- W3021993914 creator A5034491326 @default.
- W3021993914 creator A5035243580 @default.
- W3021993914 creator A5037092952 @default.
- W3021993914 creator A5037381151 @default.
- W3021993914 creator A5040647849 @default.
- W3021993914 creator A5043080647 @default.
- W3021993914 creator A5045514288 @default.
- W3021993914 creator A5046671345 @default.
- W3021993914 creator A5048114477 @default.
- W3021993914 creator A5048863528 @default.
- W3021993914 creator A5049524331 @default.
- W3021993914 creator A5049829108 @default.
- W3021993914 creator A5051289927 @default.
- W3021993914 creator A5051370807 @default.
- W3021993914 creator A5052728393 @default.
- W3021993914 creator A5052796561 @default.
- W3021993914 creator A5053074659 @default.
- W3021993914 creator A5053532132 @default.
- W3021993914 creator A5057649971 @default.
- W3021993914 creator A5060049615 @default.
- W3021993914 creator A5062526137 @default.
- W3021993914 creator A5063385291 @default.
- W3021993914 creator A5063459619 @default.
- W3021993914 creator A5064494204 @default.
- W3021993914 creator A5065217353 @default.
- W3021993914 creator A5066001988 @default.
- W3021993914 creator A5066518394 @default.
- W3021993914 creator A5066835564 @default.
- W3021993914 creator A5066879936 @default.
- W3021993914 creator A5067990670 @default.
- W3021993914 creator A5069514505 @default.
- W3021993914 creator A5071248262 @default.
- W3021993914 creator A5071933268 @default.
- W3021993914 creator A5073086587 @default.
- W3021993914 creator A5073362806 @default.
- W3021993914 creator A5074087271 @default.
- W3021993914 creator A5074514816 @default.
- W3021993914 creator A5074808099 @default.
- W3021993914 creator A5075347427 @default.
- W3021993914 creator A5075459515 @default.
- W3021993914 creator A5076319691 @default.
- W3021993914 creator A5077109568 @default.
- W3021993914 creator A5077206620 @default.
- W3021993914 creator A5077624751 @default.
- W3021993914 creator A5077901912 @default.
- W3021993914 creator A5078525701 @default.
- W3021993914 creator A5078809545 @default.