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• W3021996906 endingPage "2019" @default.
• W3021996906 startingPage "00306" @default.
• W3021996906 abstract "Background The increasing incidence of life-threatening Pneumocystis pneumonia (PCP) in non-HIV immunocompromised patients is a global concern. Yet, no reports have examined the prognostic significance of pre-existing interstitial lung disease (ILD) in non-HIV PCP. Methods We retrospectively reviewed the medical records of non-HIV PCP patients with (ILD group) or without (non-ILD group) pre-existing ILD. The clinical features and outcomes of the ILD group were compared with those of the non-ILD group. Cox regression models were constructed to identify prognostic factors. Results 74 patients were enrolled in this study. The 90-day mortality was significantly higher in the ILD group than in the non-ILD group (62.5% versus 19.0%, p<0.001). In the ILD group, patients with a higher percentage of bronchoalveolar lavage fluid neutrophils had worse outcomes compared to those having a lower percentage (p=0.026). Multivariate analyses revealed that pre-existing ILD (p=0.002) and low levels of serum albumin (p=0.009) were independent risk factors for 90-day mortality. Serum levels of β- d -glucan were significantly reduced after treatment of PCP in both groups, whereas levels of Krebs von den Lungen-6 (KL-6) significantly increased in the ILD group. In the ILD group, the 90-day mortality of patients with increasing KL-6 levels after treatment was significantly higher than those with decreasing levels (78.9% versus 0%, p=0.019). Conclusion In non-HIV PCP patients, pre-existing ILD is associated with a poorer prognosis. Prophylaxis for PCP is needed in patients with pre-existing ILD under immunosuppression." @default.
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• W3021996906 date "2020-04-01" @default.
• W3021996906 modified "2023-09-28" @default.
• W3021996906 title "Prognostic impact of pre-existing interstitial lung disease in non-HIV patients with <i>Pneumocystis</i> pneumonia" @default.
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• W3021996906 doi "https://doi.org/10.1183/23120541.00306-2019" @default.
• W3021996906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7196667" @default.
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