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- W3022007710 abstract "This chapter elucidates the design, preparation, and use of the hapten–carrier conjugates employed to elicit an immune response toward a coupled hapten. The chemical reactions described for these conjugations are functional for coupling peptides, proteins, carbohydrates, oligonucleotides, and other small organic molecules with various carrier macromolecules. The resultant conjugates are important in antibody production, immune response research, and creation of vaccines. Hapten–carrier conjugates are being used to produce extremely specific monoclonal antibodies that can recognize discrete chemical epitopes on the coupled hapten. The resulting monoclonals are often used to investigate the epitopic structure and interactions between native proteins. In many cases, the haptens used to generate these monoclonals are again small peptide segments representing crucial antigenic sites on the surface of larger proteins. Monoclonals developed from known peptide sequences will interact in highly defined ways with the protein from which the sequence originated. These antibodies can then be used as competitors to the natural interactions between a receptor and its ligand. Thus, by using antibodies generated from hapten–carrier conjugates, information can be obtained about the precise sites of binding between macromolecules." @default.
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- W3022007710 date "1996-01-01" @default.
- W3022007710 modified "2023-10-09" @default.
- W3022007710 title "Preparation of Hapten-Carrier Immunogen Conjugates" @default.
- W3022007710 doi "https://doi.org/10.1016/b978-012342335-1/50010-5" @default.
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