Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022014908> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3022014908 abstract "Purpose: C-X-C chemokine receptor type 2 (CXCR2) is a key regulator that drives immune suppression and inflammation in tumor microenvironment. CXCR2-targeted therapy has shown promising results in several solid tumors. However, the underlying mechanism of CXCR2-mediated cross-talk between gastric cancer cells and macrophages still remains unclear. Experimental Design: The expression of CXCR2 and its ligands in 155 human gastric cancer tissues was analyzed via immunohistochemistry, and the correlations with clinical characteristics were evaluated. A coculture system was established, and functional assays, including ELISA, transwell, cell viability assay, and qPCR, were performed to determine the role of the CXCR2 signaling axis in promoting gastric cancer growth and metastasis. A xenograft gastric cancer model and a lymph node metastasis model were established to study the function of CXCR2 in vivo. Results: CXCR2 expression is associated with the prognosis of patients with gastric cancer (P = 0.002). Of all the CXCR2 ligands, CXCL1 and CXCL5 can significantly promote migration of gastric cancer cells. Macrophages are the major sources of CXCL1 and CXCL5 in the gastric cancer microenvironment, and promote migration of gastric cancer cells through activating a CXCR2/STAT3 feed-forward loop. Gastric cancer cells secrete TNF-α to induce release of CXCL1 and CXCL5 from macrophages. Inhibiting CXCR2 pathway of gastric cancer cells can suppress migration and metastasis of gastric cancer in vitro and in vivo. Conclusions: Our study suggested a previously uncharacterized mechanism through which gastric cancer cells interact with macrophages to promote tumor growth and metastasis, suggesting that CXCR2 may serve as a promising therapeutic target to treat gastric cancer." @default.
- W3022014908 created "2020-05-13" @default.
- W3022014908 creator A5002487860 @default.
- W3022014908 creator A5017030270 @default.
- W3022014908 creator A5017541508 @default.
- W3022014908 creator A5020363606 @default.
- W3022014908 creator A5021822564 @default.
- W3022014908 creator A5024710933 @default.
- W3022014908 creator A5047602817 @default.
- W3022014908 creator A5051324146 @default.
- W3022014908 creator A5051458503 @default.
- W3022014908 creator A5052024256 @default.
- W3022014908 creator A5059214692 @default.
- W3022014908 creator A5074858555 @default.
- W3022014908 creator A5077972623 @default.
- W3022014908 creator A5089311418 @default.
- W3022014908 date "2019-06-01" @default.
- W3022014908 modified "2023-09-22" @default.
- W3022014908 title "A C-X-C Chemokine Receptor Type 2–Dominated Cross-talk between Tumor Cells and Macrophages Drives Gastric Cancer Metastasis" @default.
- W3022014908 hasPublicationYear "2019" @default.
- W3022014908 type Work @default.
- W3022014908 sameAs 3022014908 @default.
- W3022014908 citedByCount "0" @default.
- W3022014908 crossrefType "book-chapter" @default.
- W3022014908 hasAuthorship W3022014908A5002487860 @default.
- W3022014908 hasAuthorship W3022014908A5017030270 @default.
- W3022014908 hasAuthorship W3022014908A5017541508 @default.
- W3022014908 hasAuthorship W3022014908A5020363606 @default.
- W3022014908 hasAuthorship W3022014908A5021822564 @default.
- W3022014908 hasAuthorship W3022014908A5024710933 @default.
- W3022014908 hasAuthorship W3022014908A5047602817 @default.
- W3022014908 hasAuthorship W3022014908A5051324146 @default.
- W3022014908 hasAuthorship W3022014908A5051458503 @default.
- W3022014908 hasAuthorship W3022014908A5052024256 @default.
- W3022014908 hasAuthorship W3022014908A5059214692 @default.
- W3022014908 hasAuthorship W3022014908A5074858555 @default.
- W3022014908 hasAuthorship W3022014908A5077972623 @default.
- W3022014908 hasAuthorship W3022014908A5089311418 @default.
- W3022014908 hasConcept C121608353 @default.
- W3022014908 hasConcept C126322002 @default.
- W3022014908 hasConcept C12823836 @default.
- W3022014908 hasConcept C13373296 @default.
- W3022014908 hasConcept C179661763 @default.
- W3022014908 hasConcept C203014093 @default.
- W3022014908 hasConcept C2776107976 @default.
- W3022014908 hasConcept C2779013556 @default.
- W3022014908 hasConcept C502942594 @default.
- W3022014908 hasConcept C71924100 @default.
- W3022014908 hasConcept C7806222 @default.
- W3022014908 hasConcept C84913492 @default.
- W3022014908 hasConcept C86803240 @default.
- W3022014908 hasConcept C8891405 @default.
- W3022014908 hasConcept C96232424 @default.
- W3022014908 hasConcept C96525457 @default.
- W3022014908 hasConceptScore W3022014908C121608353 @default.
- W3022014908 hasConceptScore W3022014908C126322002 @default.
- W3022014908 hasConceptScore W3022014908C12823836 @default.
- W3022014908 hasConceptScore W3022014908C13373296 @default.
- W3022014908 hasConceptScore W3022014908C179661763 @default.
- W3022014908 hasConceptScore W3022014908C203014093 @default.
- W3022014908 hasConceptScore W3022014908C2776107976 @default.
- W3022014908 hasConceptScore W3022014908C2779013556 @default.
- W3022014908 hasConceptScore W3022014908C502942594 @default.
- W3022014908 hasConceptScore W3022014908C71924100 @default.
- W3022014908 hasConceptScore W3022014908C7806222 @default.
- W3022014908 hasConceptScore W3022014908C84913492 @default.
- W3022014908 hasConceptScore W3022014908C86803240 @default.
- W3022014908 hasConceptScore W3022014908C8891405 @default.
- W3022014908 hasConceptScore W3022014908C96232424 @default.
- W3022014908 hasConceptScore W3022014908C96525457 @default.
- W3022014908 hasLocation W30220149081 @default.
- W3022014908 hasOpenAccess W3022014908 @default.
- W3022014908 hasPrimaryLocation W30220149081 @default.
- W3022014908 hasRelatedWork W1492111426 @default.
- W3022014908 hasRelatedWork W2051267407 @default.
- W3022014908 hasRelatedWork W2062565043 @default.
- W3022014908 hasRelatedWork W2081167228 @default.
- W3022014908 hasRelatedWork W2100231487 @default.
- W3022014908 hasRelatedWork W2126956415 @default.
- W3022014908 hasRelatedWork W2156653656 @default.
- W3022014908 hasRelatedWork W2168291011 @default.
- W3022014908 hasRelatedWork W2296435524 @default.
- W3022014908 hasRelatedWork W2309341189 @default.
- W3022014908 hasRelatedWork W2388304433 @default.
- W3022014908 hasRelatedWork W2565584054 @default.
- W3022014908 hasRelatedWork W2625295223 @default.
- W3022014908 hasRelatedWork W2891069156 @default.
- W3022014908 hasRelatedWork W2915654698 @default.
- W3022014908 hasRelatedWork W2989113793 @default.
- W3022014908 hasRelatedWork W2995695923 @default.
- W3022014908 hasRelatedWork W3030284990 @default.
- W3022014908 hasRelatedWork W3032215889 @default.
- W3022014908 hasRelatedWork W3179618315 @default.
- W3022014908 isParatext "false" @default.
- W3022014908 isRetracted "false" @default.
- W3022014908 magId "3022014908" @default.
- W3022014908 workType "book-chapter" @default.