Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022033462> ?p ?o ?g. }
- W3022033462 endingPage "111046" @default.
- W3022033462 startingPage "111046" @default.
- W3022033462 abstract "The purpose of this study was to develop miconazole nitrate (MN) based solid lipid nano-carrier formulae for topical delivery to enhance its antifungal effectiveness. Miconazole nitrate loaded Solid lipid nanoparticles (MN-SLNs) were formulated using a high shear homogenization technique characterized by particle size, polydispersity index (PI), trapping efficiency (EE percent), drug loading (DL percent) and zeta potential (ZP) characteristics. Furthermore, the optimized formulae were investigated for in-vitro release, ex-vivo study, skin toxicity test, and antifungal activity. With a particle size range of 244.2 ± 27.2 nm to 493.6 ± 35.3 nm, the selected MN-SLNs were spherical shaped. A high EE product percentage ranging from 79.38 ± 2.35 percent to 95.92 ± 6.12 percent and Zeta potential ZP values ranging from-21.6 ± 7.05 mV to-31.4 ± 6.84 mV suggesting strong stability was achieved. A controlled release of MN from the SLNs up to 48 h was shown in-vitro release study. The ex-vivo study showed that the selected MN-SLN (F4) mixture exhibited higher MN flux in the skin than a 1% MN solution. Moreover, selected MN-SLN (F4) has demonstrated a higher zone of inhibition against Candida albicans than a simple drug solution. MN-SLN (F4) had the lowest toxicity value for the skin. Besides, the MN-SLNs (F4) substantially reported antifungal activity with the least histopathological improvements compared to MN-solution utilizing immune-suppressing albino rats with induced candidiasis fungal infection. It can be fulfilled that SLNs can be acquired as a promising carrier for topical delivery of poorly soluble MN." @default.
- W3022033462 created "2020-05-13" @default.
- W3022033462 creator A5000550245 @default.
- W3022033462 creator A5034073006 @default.
- W3022033462 creator A5035959895 @default.
- W3022033462 creator A5069302889 @default.
- W3022033462 date "2020-09-01" @default.
- W3022033462 modified "2023-10-07" @default.
- W3022033462 title "Influence of formulation variables on miconazole nitrate–loaded lipid based nanocarrier for topical delivery" @default.
- W3022033462 cites W1530456667 @default.
- W3022033462 cites W1579046626 @default.
- W3022033462 cites W1966952912 @default.
- W3022033462 cites W1972847156 @default.
- W3022033462 cites W1976779766 @default.
- W3022033462 cites W1977371539 @default.
- W3022033462 cites W1977755432 @default.
- W3022033462 cites W1978477577 @default.
- W3022033462 cites W1980884204 @default.
- W3022033462 cites W1983562603 @default.
- W3022033462 cites W1987252432 @default.
- W3022033462 cites W1990876023 @default.
- W3022033462 cites W1995660802 @default.
- W3022033462 cites W1997003987 @default.
- W3022033462 cites W2003093213 @default.
- W3022033462 cites W2012179823 @default.
- W3022033462 cites W2014156481 @default.
- W3022033462 cites W2016181184 @default.
- W3022033462 cites W2018504340 @default.
- W3022033462 cites W2019355258 @default.
- W3022033462 cites W2019490814 @default.
- W3022033462 cites W2024833805 @default.
- W3022033462 cites W2032675836 @default.
- W3022033462 cites W2035079262 @default.
- W3022033462 cites W2037773144 @default.
- W3022033462 cites W2044070617 @default.
- W3022033462 cites W2044903986 @default.
- W3022033462 cites W2045260358 @default.
- W3022033462 cites W2046017386 @default.
- W3022033462 cites W2048627375 @default.
- W3022033462 cites W2056995570 @default.
- W3022033462 cites W2058333783 @default.
- W3022033462 cites W2059046089 @default.
- W3022033462 cites W2059848382 @default.
- W3022033462 cites W2062280806 @default.
- W3022033462 cites W2066229664 @default.
- W3022033462 cites W2067548946 @default.
- W3022033462 cites W2069104922 @default.
- W3022033462 cites W2069572791 @default.
- W3022033462 cites W2075706054 @default.
- W3022033462 cites W2078137543 @default.
- W3022033462 cites W2082745046 @default.
- W3022033462 cites W2085167783 @default.
- W3022033462 cites W2085692671 @default.
- W3022033462 cites W2090486349 @default.
- W3022033462 cites W2101882754 @default.
- W3022033462 cites W2106531760 @default.
- W3022033462 cites W2112487751 @default.
- W3022033462 cites W2113755163 @default.
- W3022033462 cites W2120833124 @default.
- W3022033462 cites W2127685088 @default.
- W3022033462 cites W2137017984 @default.
- W3022033462 cites W2141162588 @default.
- W3022033462 cites W2142488275 @default.
- W3022033462 cites W2146408988 @default.
- W3022033462 cites W2151291833 @default.
- W3022033462 cites W2166911920 @default.
- W3022033462 cites W2252760452 @default.
- W3022033462 cites W2338601290 @default.
- W3022033462 cites W2468932732 @default.
- W3022033462 cites W2534979419 @default.
- W3022033462 cites W2549410261 @default.
- W3022033462 cites W2560131105 @default.
- W3022033462 cites W2583250963 @default.
- W3022033462 cites W2606503244 @default.
- W3022033462 cites W2615544879 @default.
- W3022033462 cites W2746905804 @default.
- W3022033462 cites W2752790083 @default.
- W3022033462 cites W2767506522 @default.
- W3022033462 cites W2773689996 @default.
- W3022033462 cites W2790036073 @default.
- W3022033462 cites W2799562270 @default.
- W3022033462 cites W2808748074 @default.
- W3022033462 cites W2843205677 @default.
- W3022033462 cites W2901584895 @default.
- W3022033462 cites W2909579525 @default.
- W3022033462 cites W2939245943 @default.
- W3022033462 doi "https://doi.org/10.1016/j.colsurfb.2020.111046" @default.
- W3022033462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32416518" @default.
- W3022033462 hasPublicationYear "2020" @default.
- W3022033462 type Work @default.
- W3022033462 sameAs 3022033462 @default.
- W3022033462 citedByCount "17" @default.
- W3022033462 countsByYear W30220334622020 @default.
- W3022033462 countsByYear W30220334622021 @default.
- W3022033462 countsByYear W30220334622022 @default.
- W3022033462 countsByYear W30220334622023 @default.
- W3022033462 crossrefType "journal-article" @default.
- W3022033462 hasAuthorship W3022033462A5000550245 @default.