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- W3022085872 abstract "This study determined whether the TMTB would identify a cognitive defect among FMS patients compared with healthy normal controls (HNC). Primary FMS patients [1990 ACR criteria] and HNC were each studied between 8:00 am and noon on a single visit. Each subject was given three simple practice TMTs followed by the timed TMTB. The primary outcome variable was the time required to complete the exercise. Also documented were the numbers of errors and the product (time x errors). A by-group analysis of variance, adjusted for demographic variables, contrasted the mean scores for pain, anxiety, depression, function, stiffness and fatigue. A total of 151 subjects were enrolled (FMS N=90; HNC N=61]). Of the FMS, 84 were female, average age 50.6 years, and 72% Caucasian. The FMS were older (50.6 versus 44.7 years, p=0.009) than the HNC, had higher pain visual analog scale (38.6, vs. 2.9 mm), and more severe insomnia (7.3 cm versus 2.0 cm). For all subjects, FMS group took longer to complete the test (60.1 vs. 45 seconds, p<0.001) and made more errors than HNC (3.3 vs. 1.3, p=0.012), products (209.3 vs. 63.9, p=0.004). FMS not taking FMS medications (N=48) differed from HNC in time (60.5 vs. 45.1 seconds, p=0.008) but not in errors. FMS still taking FMS medications (N=42) took longer (60.0 vs. 45.3, p<0.001) and made more errors (3.6 vs.1.4, p=0.007), product (229.2 vs. 68.7, p=0.003). A matched analysis with 22 one-to-one demographically matched pairs produced similarly significant results. None of the clinical measures in either group correlated with the TMTB scores. These findings demonstrated that the TMTB was capable of detecting cognitive dysfunction in FMS. Use of FMS medications compounded this defect. Attempts to correlate these findings with clinical variables failed to disclose a logical model." @default.
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- W3022085872 date "2006-04-01" @default.
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- W3022085872 title "(935)" @default.
- W3022085872 doi "https://doi.org/10.1016/j.jpain.2006.01.337" @default.
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