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- W3022121572 abstract "Granulocyte collections are apheresis-derived white blood cell components, usually about 300 ml in volume, composed of a mixture of granulocytes and other elements that are considered contaminants. Granulocytes are collected by apheresis of volunteer donors who are primed with corticosteroids or hematopoietic growth factors using centrifugal separation with a commercial blood cell separator. In general, granulocyte collections are performed employing standard leukapheresis tubing sets via peripheral venous access. As an unlicensed product, granulocyte collections have no official product specifications established by the Food and Drug Administration (FDA). Standards set by the American Association of Blood Banks have required the granulocyte apheresis unit to include a minimum of 1×1010 granulocytes in at least 75% of units tested. The minimal dosage should be at least twice this amount to detect a significant granulocyte increment in adults. The number of mature granulocytes in the product is the primary measure of the product efficacy, although control of infection in the neutropenic recipient is the ultimate indicator of the product's effectiveness. Granulocyte products contain significant numbers of T-lymphocytes, with an accompanying risk of transfusion associated graft-versus-host disease (TA-GVHD) in immunocompromised patients. A small risk for immunocompetent recipients also exists but is not considered clinically significant. To prevent the occurrence of TA-GVHD, blood components should be gamma irradiated prior to administration to immunosuppressed individuals. Adverse events experienced by recipients of granulocyte transfusions—even when compatible transfusions are administered to nonalloimmunized patients—can be significant. Common risks include fever and shaking chills, both of which can result from too-rapid infusions." @default.
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- W3022121572 date "2001-01-01" @default.
- W3022121572 modified "2023-10-16" @default.
- W3022121572 title "Granulocytes" @default.
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- W3022121572 doi "https://doi.org/10.1016/b978-012348775-9/50059-4" @default.
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