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• W3022127908 abstract "Purpose/Objective(s)Because partial breast radiation (PBI) is being tested as a modality to replace whole breast irradiation, we wanted to try and improve upon side-effects of a common form of PBI treatment, the Mammosite Catheter.Primary aim○ To determine if Mammosite Catheter optimization using multiple dwell position delivery decreases skin toxicity over historically reported skin toxicity with the single dwell delivery method.Secondary aim○ Compare the delivered multiple dwell position plan to a mock single dwell position plan to:○ Confirm equal or better planning target volume (PTV) coverage○ Confirm equal or less normal tissue dose○ Record skin parameters to determine the parameters most predictive of skin toxicity on this trial for future studies.Materials/MethodsWe wanted to determine if we could decrease the skin dose and potentially the skin toxicity from MammoSite breast brachytherapy by using a multiple dwell dose delivery method. As a proof in principle we retrospectively generated multiple dwell plans and compared them to the single dwell plan that was delivered to four consecutive patients and a benchmark case supplied for the Phase III trial. We measured and compared parameters we suspect will predict skin toxicity, including: maximum dose at 1mm, 2mm and 3mm skin depth; and the volume of skin receiving certain percentages of dose.ResultsWe were able to show that in all cases with a balloon-to-skin distance of 6–12 mm that there was a decrease in skin dose for all of these measured parameters (Table 1).Tabled 1ConclusionsWe are now testing these hypotheses in a phase II study where we will generate single dwell and multiple dwell Mammosite treatment plans, and deliver treatment only by the multiple dwell plan and follow patients for skin toxicity. This study will allow us to determine if modifying radiation delivery using the Mammosite Catheter can reduce skin toxicity, thereby improving QOL from this treatment. Purpose/Objective(s)Because partial breast radiation (PBI) is being tested as a modality to replace whole breast irradiation, we wanted to try and improve upon side-effects of a common form of PBI treatment, the Mammosite Catheter.Primary aim○ To determine if Mammosite Catheter optimization using multiple dwell position delivery decreases skin toxicity over historically reported skin toxicity with the single dwell delivery method.Secondary aim○ Compare the delivered multiple dwell position plan to a mock single dwell position plan to:○ Confirm equal or better planning target volume (PTV) coverage○ Confirm equal or less normal tissue dose○ Record skin parameters to determine the parameters most predictive of skin toxicity on this trial for future studies. Because partial breast radiation (PBI) is being tested as a modality to replace whole breast irradiation, we wanted to try and improve upon side-effects of a common form of PBI treatment, the Mammosite Catheter. Primary aim ○ To determine if Mammosite Catheter optimization using multiple dwell position delivery decreases skin toxicity over historically reported skin toxicity with the single dwell delivery method. Secondary aim ○ Compare the delivered multiple dwell position plan to a mock single dwell position plan to: ○ Confirm equal or better planning target volume (PTV) coverage ○ Confirm equal or less normal tissue dose ○ Record skin parameters to determine the parameters most predictive of skin toxicity on this trial for future studies. Materials/MethodsWe wanted to determine if we could decrease the skin dose and potentially the skin toxicity from MammoSite breast brachytherapy by using a multiple dwell dose delivery method. As a proof in principle we retrospectively generated multiple dwell plans and compared them to the single dwell plan that was delivered to four consecutive patients and a benchmark case supplied for the Phase III trial. We measured and compared parameters we suspect will predict skin toxicity, including: maximum dose at 1mm, 2mm and 3mm skin depth; and the volume of skin receiving certain percentages of dose. We wanted to determine if we could decrease the skin dose and potentially the skin toxicity from MammoSite breast brachytherapy by using a multiple dwell dose delivery method. As a proof in principle we retrospectively generated multiple dwell plans and compared them to the single dwell plan that was delivered to four consecutive patients and a benchmark case supplied for the Phase III trial. We measured and compared parameters we suspect will predict skin toxicity, including: maximum dose at 1mm, 2mm and 3mm skin depth; and the volume of skin receiving certain percentages of dose. ResultsWe were able to show that in all cases with a balloon-to-skin distance of 6–12 mm that there was a decrease in skin dose for all of these measured parameters (Table 1).Tabled 1 We were able to show that in all cases with a balloon-to-skin distance of 6–12 mm that there was a decrease in skin dose for all of these measured parameters (Table 1). ConclusionsWe are now testing these hypotheses in a phase II study where we will generate single dwell and multiple dwell Mammosite treatment plans, and deliver treatment only by the multiple dwell plan and follow patients for skin toxicity. This study will allow us to determine if modifying radiation delivery using the Mammosite Catheter can reduce skin toxicity, thereby improving QOL from this treatment. We are now testing these hypotheses in a phase II study where we will generate single dwell and multiple dwell Mammosite treatment plans, and deliver treatment only by the multiple dwell plan and follow patients for skin toxicity. This study will allow us to determine if modifying radiation delivery using the Mammosite Catheter can reduce skin toxicity, thereby improving QOL from this treatment." @default.
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• W3022127908 date "2006-11-01" @default.
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• W3022127908 doi "https://doi.org/10.1016/j.ijrobp.2006.07.455" @default.
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