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• W3022144464 abstract "Non-alcoholic fatty liver disease (NAFLD) is associated with cardiovascular disease (CVD) in patients with type 2 diabetes; nonetheless, it is unknown whether the relationship between NAFLD and CVD occurs also in subjects with prediabetes. Herein, we evaluated whether NAFLD is associated with prevalent CVD in subjects with different glucose tolerance states independently of cardiovascular risk factors. Presence of NALFD, defined by liver ultrasound, and its association with prevalent composite and individual CVD, including coronary artery disease (CAD) and cerebrovascular disease, was assessed in a cohort of 1254 Caucasian subjects classified as having normal glucose tolerance (NGT, n = 517), prediabetes (n = 397) or type 2 diabetes (n = 340). Prevalence of NAFLD in the study population was 47.9%. Presence of NAFLD was linked to an augmented prevalence of composite CVD and individual CAD in all the three glucose tolerance groups. In a logistic regression model adjusted for several cardio-metabolic risk factors, subjects with NGT and NAFLD exhibited a 3.2- and 3.4-fold increased risk of having CVD or CAD, respectively, as compared with those without NAFLD. Similarly, subjects with prediabetes and NAFLD showed an increased risk of having CVD or CAD by 2.3- and 2.0-fold, respectively, in comparison to their counterpart without NAFLD. Within the group with type 2 diabetes, subjects having NAFLD displayed a 2.3- and 2.0-fold higher risk of having CVD or CAD, respectively, in comparison to those without NAFLD. Ultrasonography-defined NAFLD is independently associated with an increased risk of having CVD in individuals with different glucose tolerance. The authors declare that they have no financial and non-financial competing interests. Data S1: Figure S1 Prevalence of composite CVD (A), CAD (B) and cerebrovascular disease (C) in the study population without ultrasonography-defined NAFLD subdivided according to glucose tolerance Data S2: Figure S2 Prevalence of composite CVD (A), CAD (B) and cerebrovascular disease (C) in the study population with ultrasonography-defined NAFLD subdivided according to glucose tolerance Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
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• W3022144464 date "2020-05-31" @default.
• W3022144464 modified "2023-09-28" @default.
• W3022144464 title "Non‐alcoholic fatty liver disease is associated with cardiovascular disease in subjects with different glucose tolerance" @default.
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• W3022144464 doi "https://doi.org/10.1002/dmrr.3333" @default.
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