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- W3022152610 endingPage "11819" @default.
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- W3022152610 abstract "Significance Age-related hearing loss is the most common cause of hearing loss. Here, we show that medial olivocochlear feedback mediates resistance to age-related hearing loss—presbycusis—and that this occurs via the α9α10 cholinergic nicotinic receptor complexes on outer hair cells. These findings are particularly promising because they provide a proof of principle supporting the enhancement of the medial olivocochlear system as a viable approach for prevention or treatment of age-related hearing loss. Therefore, it opens the way to the design of novel positive modulators of α9α10 nAChR receptors for clinical use in the prevention of both noise and age-related hearing loss." @default.
- W3022152610 created "2020-05-13" @default.
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- W3022152610 date "2020-05-11" @default.
- W3022152610 modified "2023-10-16" @default.
- W3022152610 title "Preventing presbycusis in mice with enhanced medial olivocochlear feedback" @default.
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