Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022162017> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W3022162017 abstract "Abstract In view of the observation that the concentration of hydrogen sulfide in brains with Alzheimer’s disease (AD) is lower than that in normal brains and in line with our previous studies indicating that additional content in the aqueous environment (milieu) of a peptide can change its local energetic preference from a polyproline II (P) to a β conformation (and therefore its tendency to form the β‐chain structures that lead to the amyloid plaques associated with the disease), we have studied the effect of H 2 S concentration on such propensity in a simple model peptide, the alanine dipeptide (ADP). The two concentration states are represented by ADP(H 2 O) 18 (H 2 S) and ADP(H 2 O) 18 (H 2 S) 2 . Ab initio calculations of these structures show that the lowest energy of the former is a β conformation while that of the latter is a P, mirroring the observed AD results and strengthening our proposal that amyloid diseases are better viewed in the context of a protein milieu‐folding paradigm." @default.
- W3022162017 created "2020-05-13" @default.
- W3022162017 creator A5022441689 @default.
- W3022162017 creator A5068503435 @default.
- W3022162017 date "2020-05-07" @default.
- W3022162017 modified "2023-09-27" @default.
- W3022162017 title "Hydrogen sulfide concentration in the milieu of the hydrated alanine dipeptide determines its polyproline II‐beta propensity: Main chain contribution to the energetic origin of the formation of amyloid" @default.
- W3022162017 cites W1963925340 @default.
- W3022162017 cites W1994193970 @default.
- W3022162017 cites W2017738553 @default.
- W3022162017 cites W2027314857 @default.
- W3022162017 cites W2077608361 @default.
- W3022162017 cites W2089383475 @default.
- W3022162017 cites W2107160928 @default.
- W3022162017 cites W2112850441 @default.
- W3022162017 cites W2160502019 @default.
- W3022162017 cites W2335520176 @default.
- W3022162017 cites W2464726538 @default.
- W3022162017 cites W2513868860 @default.
- W3022162017 cites W2552043470 @default.
- W3022162017 cites W2560598375 @default.
- W3022162017 cites W2614053601 @default.
- W3022162017 cites W2784100348 @default.
- W3022162017 cites W2901493381 @default.
- W3022162017 cites W2924528101 @default.
- W3022162017 doi "https://doi.org/10.1002/bip.23356" @default.
- W3022162017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32379917" @default.
- W3022162017 hasPublicationYear "2020" @default.
- W3022162017 type Work @default.
- W3022162017 sameAs 3022162017 @default.
- W3022162017 citedByCount "0" @default.
- W3022162017 crossrefType "journal-article" @default.
- W3022162017 hasAuthorship W3022162017A5022441689 @default.
- W3022162017 hasAuthorship W3022162017A5068503435 @default.
- W3022162017 hasBestOaLocation W30221620172 @default.
- W3022162017 hasConcept C109300003 @default.
- W3022162017 hasConcept C151730666 @default.
- W3022162017 hasConcept C178790620 @default.
- W3022162017 hasConcept C179104552 @default.
- W3022162017 hasConcept C185592680 @default.
- W3022162017 hasConcept C204328495 @default.
- W3022162017 hasConcept C2776156579 @default.
- W3022162017 hasConcept C2777633098 @default.
- W3022162017 hasConcept C2779138802 @default.
- W3022162017 hasConcept C2779281246 @default.
- W3022162017 hasConcept C2779343474 @default.
- W3022162017 hasConcept C2780564542 @default.
- W3022162017 hasConcept C2781442258 @default.
- W3022162017 hasConcept C518881349 @default.
- W3022162017 hasConcept C55493867 @default.
- W3022162017 hasConcept C71240020 @default.
- W3022162017 hasConcept C86803240 @default.
- W3022162017 hasConceptScore W3022162017C109300003 @default.
- W3022162017 hasConceptScore W3022162017C151730666 @default.
- W3022162017 hasConceptScore W3022162017C178790620 @default.
- W3022162017 hasConceptScore W3022162017C179104552 @default.
- W3022162017 hasConceptScore W3022162017C185592680 @default.
- W3022162017 hasConceptScore W3022162017C204328495 @default.
- W3022162017 hasConceptScore W3022162017C2776156579 @default.
- W3022162017 hasConceptScore W3022162017C2777633098 @default.
- W3022162017 hasConceptScore W3022162017C2779138802 @default.
- W3022162017 hasConceptScore W3022162017C2779281246 @default.
- W3022162017 hasConceptScore W3022162017C2779343474 @default.
- W3022162017 hasConceptScore W3022162017C2780564542 @default.
- W3022162017 hasConceptScore W3022162017C2781442258 @default.
- W3022162017 hasConceptScore W3022162017C518881349 @default.
- W3022162017 hasConceptScore W3022162017C55493867 @default.
- W3022162017 hasConceptScore W3022162017C71240020 @default.
- W3022162017 hasConceptScore W3022162017C86803240 @default.
- W3022162017 hasIssue "7" @default.
- W3022162017 hasLocation W30221620171 @default.
- W3022162017 hasLocation W30221620172 @default.
- W3022162017 hasOpenAccess W3022162017 @default.
- W3022162017 hasPrimaryLocation W30221620171 @default.
- W3022162017 hasRelatedWork W1998227221 @default.
- W3022162017 hasRelatedWork W2054686427 @default.
- W3022162017 hasRelatedWork W2067366939 @default.
- W3022162017 hasRelatedWork W2074988859 @default.
- W3022162017 hasRelatedWork W2127765628 @default.
- W3022162017 hasRelatedWork W2151038046 @default.
- W3022162017 hasRelatedWork W2165292497 @default.
- W3022162017 hasRelatedWork W2927518399 @default.
- W3022162017 hasRelatedWork W3022162017 @default.
- W3022162017 hasRelatedWork W3185508373 @default.
- W3022162017 hasVolume "111" @default.
- W3022162017 isParatext "false" @default.
- W3022162017 isRetracted "false" @default.
- W3022162017 magId "3022162017" @default.
- W3022162017 workType "article" @default.