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- W3022172212 abstract "Abstract POXylated polyurea dendrimer nanoparticles (PURE G4 OOx 48 ) are loaded with sildenafil (SDF) by a supercritical carbon dioxide–assisted (scCO 2 ) impregnation. Further supercritical CO 2 ‐assisted spray drying (SASD) leads to hybrid nano‐in‐micro dry powder formulations that are investigated aiming at efficient pulmonary delivery of SDF in pulmonary arterial hypertension treatment. This is the first report of the production of poly(D,L‐lactide‐ co ‐glycolide)‐cholesterol (PLGA‐Chol) microparticles processed by SASD. The optimized formulation of nano‐in‐microparticles is composed of PLGA, Chol, and PURE G4 OOx 48 , loaded with SDF solutions in a 77:23 ratio (PLGA‐Chol:dendrimer, w/w). The dry powders are fully characterized and found to be highly biodegradable and biocompatible, and the SDF release profile evaluates under different pH values. The median mass average diameter (MMAD) of the nano‐in‐micro systems varies between 2.57 and 5 µm and the fine particle fraction (FPF) between 36% and 29% for PURE G4 OMeOx 48 [PLGA‐Chol] and PURE G4 OEtOx 48 [PLGA‐Chol], respectively. The data validate the potential use of these new formulations in inhalation therapy. In vitro studies are also carried out in order to evaluate the effect of the free drug in cell viability and formulations cytotoxicity." @default.
- W3022172212 created "2020-05-13" @default.
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- W3022172212 date "2020-05-06" @default.
- W3022172212 modified "2023-10-18" @default.
- W3022172212 title "Nano‐in‐Micro Sildenafil Dry Powder Formulations for the Treatment of Pulmonary Arterial Hypertension Disorders: The Synergic Effect of POxylated Polyurea Dendrimers, PLGA, and Cholesterol" @default.
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- W3022172212 doi "https://doi.org/10.1002/ppsc.201900447" @default.
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