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- W3022194924 abstract "Dealing in practice with a priori (structural) unidentifiable models is a difficult problem. Often the natural approaches for achieving identifiability, i.e. model structure simplification or design of more informative I-O experiments, are not usable in physiological and clinical investigations. We discuss here some theoretical and practical aspects related to the numerical identification of a priori unidentifiable models. As case study a linear time invariant model of glucose kinetics is considered with I-O data for identification generated from multiple steady state tracer experiments. Different strategies for resolving ambiguity due to unidentifiability are used, including the derivation of parameter-bounds and the explicit consideration of independent knowledge on the system. Some theoretical aspects of the problem are also discussed, more precisely comments are made on the recently proposed definitions of interval identifiability and quasi-identifiability for unidentifiable systems." @default.
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- W3022194924 date "1987-01-01" @default.
- W3022194924 modified "2023-10-18" @default.
- W3022194924 title "THEORETICAL ASPECTS AND PRACTICAL STRATEGIES FOR THE IDENTIFICATION OF UNIDENTIFIABLE COMPARTMENTAL SYSTEMS" @default.
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- W3022194924 doi "https://doi.org/10.1016/b978-0-08-034929-9.50012-1" @default.
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