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- W3022199624 abstract "Because polygenic risk scores (PRSs) for coronary heart disease (CHD) are derived from mainly European ancestry (EA) cohorts, their validity in African ancestry (AA) and Hispanic ethnicity (HE) individuals is unclear. We investigated associations of “restricted” and genome-wide PRSs with CHD in three major racial and ethnic groups in the U.S. The eMERGE cohort (mean age 48 ± 14 years, 58% female) included 45,645 EA, 7,597 AA, and 2,493 HE individuals. We assessed two restricted PRSs (PRSTikkanen and PRSTada; 28 and 50 variants, respectively) and two genome-wide PRSs (PRSmetaGRS and PRSLDPred; 1.7 M and 6.6 M variants, respectively) derived from EA cohorts. Over a median follow-up of 11.1 years, 2,652 incident CHD events occurred. Hazard and odds ratios for the association of PRSs with CHD were similar in EA and HE cohorts but lower in AA cohorts. Genome-wide PRSs were more strongly associated with CHD than restricted PRSs were. PRSmetaGRS, the best performing PRS, was associated with CHD in all three cohorts; hazard ratios (95% CI) per 1 SD increase were 1.53 (1.46–1.60), 1.53 (1.23–1.90), and 1.27 (1.13–1.43) for incident CHD in EA, HE, and AA individuals, respectively. The hazard ratios were comparable in the EA and HE cohorts (pinteraction = 0.77) but were significantly attenuated in AA individuals (pinteraction = 2.9 × 10−3). These results highlight the potential clinical utility of PRSs for CHD as well as the need to assemble diverse cohorts to generate ancestry- and ethnicity PRSs. Because polygenic risk scores (PRSs) for coronary heart disease (CHD) are derived from mainly European ancestry (EA) cohorts, their validity in African ancestry (AA) and Hispanic ethnicity (HE) individuals is unclear. We investigated associations of “restricted” and genome-wide PRSs with CHD in three major racial and ethnic groups in the U.S. The eMERGE cohort (mean age 48 ± 14 years, 58% female) included 45,645 EA, 7,597 AA, and 2,493 HE individuals. We assessed two restricted PRSs (PRSTikkanen and PRSTada; 28 and 50 variants, respectively) and two genome-wide PRSs (PRSmetaGRS and PRSLDPred; 1.7 M and 6.6 M variants, respectively) derived from EA cohorts. Over a median follow-up of 11.1 years, 2,652 incident CHD events occurred. Hazard and odds ratios for the association of PRSs with CHD were similar in EA and HE cohorts but lower in AA cohorts. Genome-wide PRSs were more strongly associated with CHD than restricted PRSs were. PRSmetaGRS, the best performing PRS, was associated with CHD in all three cohorts; hazard ratios (95% CI) per 1 SD increase were 1.53 (1.46–1.60), 1.53 (1.23–1.90), and 1.27 (1.13–1.43) for incident CHD in EA, HE, and AA individuals, respectively. The hazard ratios were comparable in the EA and HE cohorts (pinteraction = 0.77) but were significantly attenuated in AA individuals (pinteraction = 2.9 × 10−3). These results highlight the potential clinical utility of PRSs for CHD as well as the need to assemble diverse cohorts to generate ancestry- and ethnicity PRSs." @default.
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- W3022199624 date "2020-05-01" @default.
- W3022199624 modified "2023-10-15" @default.
- W3022199624 title "Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups" @default.
- W3022199624 cites W176696043 @default.
- W3022199624 cites W1874197506 @default.
- W3022199624 cites W1911952697 @default.
- W3022199624 cites W1980991473 @default.
- W3022199624 cites W1997420125 @default.
- W3022199624 cites W2009487735 @default.
- W3022199624 cites W2019794729 @default.
- W3022199624 cites W2021645048 @default.
- W3022199624 cites W2027867013 @default.
- W3022199624 cites W2064337796 @default.
- W3022199624 cites W2099085143 @default.
- W3022199624 cites W2102213696 @default.
- W3022199624 cites W2105714645 @default.
- W3022199624 cites W2110048796 @default.
- W3022199624 cites W2110976368 @default.
- W3022199624 cites W2115762367 @default.
- W3022199624 cites W2127757090 @default.
- W3022199624 cites W2134783591 @default.
- W3022199624 cites W2135313485 @default.
- W3022199624 cites W2137249087 @default.
- W3022199624 cites W2140479040 @default.
- W3022199624 cites W2152135705 @default.
- W3022199624 cites W2161633633 @default.
- W3022199624 cites W2165670510 @default.
- W3022199624 cites W2168497248 @default.
- W3022199624 cites W2169795969 @default.
- W3022199624 cites W2238851414 @default.
- W3022199624 cites W2277439059 @default.
- W3022199624 cites W2296321737 @default.
- W3022199624 cites W2303883198 @default.
- W3022199624 cites W2317648909 @default.
- W3022199624 cites W2345958530 @default.
- W3022199624 cites W2510973425 @default.
- W3022199624 cites W2511515754 @default.
- W3022199624 cites W2516351633 @default.
- W3022199624 cites W2521147375 @default.
- W3022199624 cites W2549881333 @default.
- W3022199624 cites W2551232524 @default.
- W3022199624 cites W2590415274 @default.
- W3022199624 cites W2590902687 @default.
- W3022199624 cites W2598022332 @default.
- W3022199624 cites W2619767973 @default.
- W3022199624 cites W2619889663 @default.
- W3022199624 cites W2735404270 @default.
- W3022199624 cites W2775393828 @default.
- W3022199624 cites W2793191510 @default.
- W3022199624 cites W2794819865 @default.
- W3022199624 cites W2801098573 @default.
- W3022199624 cites W2803332630 @default.
- W3022199624 cites W2886752110 @default.
- W3022199624 cites W2895366584 @default.
- W3022199624 cites W2901728784 @default.
- W3022199624 cites W2913705661 @default.
- W3022199624 cites W2921012991 @default.
- W3022199624 cites W2924473034 @default.
- W3022199624 cites W2932671560 @default.
- W3022199624 cites W2949848466 @default.
- W3022199624 cites W2950135831 @default.
- W3022199624 cites W2950814369 @default.
- W3022199624 cites W2952785442 @default.
- W3022199624 cites W2955214642 @default.
- W3022199624 cites W2965553447 @default.
- W3022199624 cites W3004839449 @default.
- W3022199624 cites W3015263100 @default.
- W3022199624 cites W4210347219 @default.
- W3022199624 doi "https://doi.org/10.1016/j.ajhg.2020.04.002" @default.
- W3022199624 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7212267" @default.
- W3022199624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32386537" @default.
- W3022199624 hasPublicationYear "2020" @default.
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