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• W3022202102 abstract "Increasingly being recognized is the role of the complex microenvironment to regulate cell phenotype; however, the cell culture systems used to study these effects in vitro are lagging. The complex microenvironment is a combination of biological interactions, chemical factors, and mechanical stimuli. Many devices have been designed to probe the effects of one mechanical stimulus, but few are capable of systematically interrogating all combinations of mechanical stimuli with independent control. To address this gap, we have developed the MechanoBioTester platform, a decoupled, multistimulus cell culture model for studying the cellular response to complex microenvironments in vitro. The system uses an engineered elastomeric chamber with a specially defined region for incorporating different target materials to act as the cell culture substrate. We have tested the system with several target materials, including polydimethylsiloxane elastomer, polyacrylamide gel, poly(1,8-octanediol citrate) elastomer, and type I collagen gel for both two-dimensional (2D) and three-dimensional (3D) cocultures. Additionally, when the chamber is connected to a flow circuit and our stretching device, stimuli in the form of fluid flow, cyclic stretch, and hydrostatic pressure are able to be imparted with independent control. We validated the device using experimental and computational methods to define a range of capabilities relevant to physiological microenvironments. The MechanoBioTester platform promises to function as a model system for mechanobiology, biomaterial design, and drug discovery applications that focus on probing the impact of a complex microenvironment in an in vitro setting. The protocol described provides the details characterizing the MechanoBioTester system, the steps for fabricating the MechanoBioTester chamber, and the procedure for operating the MechanoBioTester system to stimulate cells." @default.
• W3022202102 created "2020-05-13" @default.
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• W3022202102 date "2020-05-08" @default.
• W3022202102 modified "2023-09-26" @default.
• W3022202102 title "MechanoBioTester: A Decoupled Multistimulus Cell Culture Device for Studying Complex Microenvironments <i>In Vitro</i>" @default.
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• W3022202102 doi "https://doi.org/10.1021/acsbiomaterials.0c00498" @default.
• W3022202102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7377433" @default.
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