FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022248045> ?p ?o ?g. }

• W3022248045 endingPage "e9072" @default.
• W3022248045 startingPage "e9072" @default.
• W3022248045 abstract "Optimal ventilation strategies during cardiopulmonary resuscitation are still heavily debated and poorly understood. So far, no convincing evidence could be presented in favour of outcome relevance and necessity of specific ventilation patterns. In recent years, alternative models to the guideline-based intermittent positive pressure ventilation (IPPV) have been proposed. In this randomized controlled trial, we evaluated a bi-level ventilation approach in a porcine model to assess possible physiological advantages for the pulmonary system as well as resulting changes in neuroinflammation compared to standard measures.Sixteen male German landrace pigs were anesthetized and instrumented with arterial and venous catheters. Ventricular fibrillation was induced and the animals were left untreated and without ventilation for 4 minutes. After randomization, the animals were assigned to either the guideline-based group (IPPV, tidal volume 8-10 ml/kg, respiratory rate 10/min, FiO21.0) or the bi-level group (inspiratory pressure levels 15-17 cmH2O/5cmH2O, respiratory rate 10/min, FiO21.0). Mechanical chest compressions and interventional ventilation were initiated and after 5 minutes, blood samples, including ventilation/perfusion measurements via multiple inert gas elimination technique, were taken. After 8 minutes, advanced life support including adrenaline administration and defibrillations were started for up to 4 cycles. Animals achieving ROSC were monitored for 6 hours and lungs and brain tissue were harvested for further analyses.Five of the IPPV and four of the bi-level animals achieved ROSC. While there were no significant differences in gas exchange or hemodynamic values, bi-level treated animals showed less pulmonary shunt directly after ROSC and a tendency to lower inspiratory pressures during CPR. Additionally, cytokine expression of tumour necrosis factor alpha was significantly reduced in hippocampal tissue compared to IPPV animals.Bi-level ventilation with a constant positive end expiratory pressure and pressure-controlled ventilation is not inferior in terms of oxygenation and decarboxylation when compared to guideline-based IPPV ventilation. Additionally, bi-level ventilation showed signs for a potentially ameliorated neurological outcome as well as less pulmonary shunt following experimental resuscitation. Given the restrictions of the animal model, these advantages should be further examined." @default.
• W3022248045 created "2020-05-13" @default.
• W3022248045 creator A5002911027 @default.
• W3022248045 creator A5003253841 @default.
• W3022248045 creator A5008182038 @default.
• W3022248045 creator A5023158144 @default.
• W3022248045 creator A5060825930 @default.
• W3022248045 creator A5078036143 @default.
• W3022248045 creator A5081721519 @default.
• W3022248045 date "2020-04-29" @default.
• W3022248045 modified "2023-10-04" @default.
• W3022248045 title "Bi-Level ventilation decreases pulmonary shunt and modulates neuroinflammation in a cardiopulmonary resuscitation model" @default.
• W3022248045 cites W1801618324 @default.
• W3022248045 cites W1970269618 @default.
• W3022248045 cites W1980952535 @default.
• W3022248045 cites W2027950463 @default.
• W3022248045 cites W2038611949 @default.
• W3022248045 cites W2056751727 @default.
• W3022248045 cites W2058499472 @default.
• W3022248045 cites W2093864295 @default.
• W3022248045 cites W2098969391 @default.
• W3022248045 cites W2119404482 @default.
• W3022248045 cites W2138548385 @default.
• W3022248045 cites W2172732732 @default.
• W3022248045 cites W2176287890 @default.
• W3022248045 cites W2221149713 @default.
• W3022248045 cites W2349775093 @default.
• W3022248045 cites W2430175290 @default.
• W3022248045 cites W2594649609 @default.
• W3022248045 cites W2761300390 @default.
• W3022248045 cites W2763078813 @default.
• W3022248045 cites W2797718899 @default.
• W3022248045 cites W2889378235 @default.
• W3022248045 cites W2949333891 @default.
• W3022248045 cites W142643154 @default.
• W3022248045 doi "https://doi.org/10.7717/peerj.9072" @default.
• W3022248045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7195831" @default.
• W3022248045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32377456" @default.
• W3022248045 hasPublicationYear "2020" @default.
• W3022248045 type Work @default.
• W3022248045 sameAs 3022248045 @default.
• W3022248045 citedByCount "2" @default.
• W3022248045 countsByYear W30222480452022 @default.
• W3022248045 crossrefType "journal-article" @default.
• W3022248045 hasAuthorship W3022248045A5002911027 @default.
• W3022248045 hasAuthorship W3022248045A5003253841 @default.
• W3022248045 hasAuthorship W3022248045A5008182038 @default.
• W3022248045 hasAuthorship W3022248045A5023158144 @default.
• W3022248045 hasAuthorship W3022248045A5060825930 @default.
• W3022248045 hasAuthorship W3022248045A5078036143 @default.
• W3022248045 hasAuthorship W3022248045A5081721519 @default.
• W3022248045 hasBestOaLocation W30222480451 @default.
• W3022248045 hasConcept C126322002 @default.
• W3022248045 hasConcept C127413603 @default.
• W3022248045 hasConcept C164705383 @default.
• W3022248045 hasConcept C178853913 @default.
• W3022248045 hasConcept C200457457 @default.
• W3022248045 hasConcept C2777055891 @default.
• W3022248045 hasConcept C2777080012 @default.
• W3022248045 hasConcept C2777257755 @default.
• W3022248045 hasConcept C2778165595 @default.
• W3022248045 hasConcept C2778917391 @default.
• W3022248045 hasConcept C2779589923 @default.
• W3022248045 hasConcept C2780968331 @default.
• W3022248045 hasConcept C2781005686 @default.
• W3022248045 hasConcept C42219234 @default.
• W3022248045 hasConcept C534529494 @default.
• W3022248045 hasConcept C71924100 @default.
• W3022248045 hasConcept C78519656 @default.
• W3022248045 hasConceptScore W3022248045C126322002 @default.
• W3022248045 hasConceptScore W3022248045C127413603 @default.
• W3022248045 hasConceptScore W3022248045C164705383 @default.
• W3022248045 hasConceptScore W3022248045C178853913 @default.
• W3022248045 hasConceptScore W3022248045C200457457 @default.
• W3022248045 hasConceptScore W3022248045C2777055891 @default.
• W3022248045 hasConceptScore W3022248045C2777080012 @default.
• W3022248045 hasConceptScore W3022248045C2777257755 @default.
• W3022248045 hasConceptScore W3022248045C2778165595 @default.
• W3022248045 hasConceptScore W3022248045C2778917391 @default.
• W3022248045 hasConceptScore W3022248045C2779589923 @default.
• W3022248045 hasConceptScore W3022248045C2780968331 @default.
• W3022248045 hasConceptScore W3022248045C2781005686 @default.
• W3022248045 hasConceptScore W3022248045C42219234 @default.
• W3022248045 hasConceptScore W3022248045C534529494 @default.
• W3022248045 hasConceptScore W3022248045C71924100 @default.
• W3022248045 hasConceptScore W3022248045C78519656 @default.
• W3022248045 hasLocation W30222480451 @default.
• W3022248045 hasLocation W30222480452 @default.
• W3022248045 hasLocation W30222480453 @default.
• W3022248045 hasLocation W30222480454 @default.
• W3022248045 hasOpenAccess W3022248045 @default.
• W3022248045 hasPrimaryLocation W30222480451 @default.
• W3022248045 hasRelatedWork W2035319479 @default.
• W3022248045 hasRelatedWork W2039312047 @default.
• W3022248045 hasRelatedWork W2082840273 @default.
• W3022248045 hasRelatedWork W2278208905 @default.
• W3022248045 hasRelatedWork W2366141251 @default.
• W3022248045 hasRelatedWork W2811329826 @default.

• next