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- W3022257975 abstract "1.Rats with spontaneous recurrent seizures (SRS) were obtained by injection of kainic acid (KA; 10 mg/kg SC) to drug-naive rats that regularly developed wet-dog shakes followed by complex partial seizures and status epilepticus. Three to five weeks later, the rats with manifest SRS were selected.2.The SRS rats were challenged with KA (10 mg/kg SC). The seizures induced in SRS rats by KA were similar to SRS regarding their clinical stage and duration (mean duration of seizures: 44 sec and 43 sec, respectively). The frequency of seizures was, however, increased compared with the frequency of SRS in control, vehicle-treated SRS rats (mean frequency of seizures: 12.9 and 0.4 per 3 hr, respectively). The KA-induced seizures in SRS rats differ behaviorally from KA-induced seizures in naive rats—namely, neither wet-dog shakes nor the status epilepticus could be induced.3.Repeated injection of an equal dose of KA, applied to the SRS rats 1 day after the previous KA challenge, did not induce seizures. The loss of seizure susceptibility to KA was only temporary, as shown after a 7-day drug-free period, when the repeated injection of KA regained its seizure-triggering capacity.4.The results indicate that reactivity to the seizure-inducing agent kainic acid changes in rats with spontaneous recurrent seizures." @default.
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- W3022257975 date "1979-09-01" @default.
- W3022257975 modified "2023-09-26" @default.
- W3022257975 title "Effects op barbiturates on astrocytes" @default.
- W3022257975 doi "https://doi.org/10.1016/0361-9230(79)90180-1" @default.
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