FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022289501> ?p ?o ?g. }

• W3022289501 abstract "ABSTRACT GCN codons are over-represented in initial codons of ORFs of prokaryote and eukaryote mRNAs. We describe a ribosome rRNA-protein surface that interacts with an mRNA GCN codon when next-in-line for the ribosome A site. The interaction surface is comprised of the edges of two stacked rRNA bases: the Watson-Crick edge of 16S/18S rRNA C1054 and adjacent Hoogsteen edge of A1196 ( Escherichia coli 16S rRNA numbering). Also part of the interaction surface, the planar guanidinium group of a conserved Arginine (R146 of yeast ribosomal protein Rps3) is stacked adjacent to A1196. On its other side, the interaction surface is anchored to the ribosome A site through base stacking of C1054 with the wobble anticodon base of the A-site tRNA. Using Molecular Dynamics simulations of a 495-residue subsystem of translocating ribosomes, we observe base pairing of C1054 to nucleotide G at position 1 of the next-in-line codon, consistent with previous cryo-EM observations, and hydrogen bonding of A1196 and R146 to C at position 2. Hydrogen bonding to both of these codon positions is significantly weakened when C at position 2 is changed to G, A or U. These sequence-sensitive mRNA-ribosome interactions at the C 1054- A 1196- R 146 (CAR) surface potentially contribute to GCN-mediated regulation of protein translation." @default.
• W3022289501 created "2020-05-13" @default.
• W3022289501 creator A5045387880 @default.
• W3022289501 creator A5046367313 @default.
• W3022289501 creator A5050443876 @default.
• W3022289501 creator A5054954864 @default.
• W3022289501 creator A5077468388 @default.
• W3022289501 creator A5078936621 @default.
• W3022289501 creator A5087286790 @default.
• W3022289501 date "2020-04-29" @default.
• W3022289501 modified "2023-09-26" @default.
• W3022289501 title "A Ribosome Interaction Surface Sensitive to mRNA GCN Periodicity" @default.
• W3022289501 cites W1538258919 @default.
• W3022289501 cites W1975580333 @default.
• W3022289501 cites W1981191447 @default.
• W3022289501 cites W2004822259 @default.
• W3022289501 cites W2016480108 @default.
• W3022289501 cites W2025569664 @default.
• W3022289501 cites W2035266068 @default.
• W3022289501 cites W2035667852 @default.
• W3022289501 cites W2040485185 @default.
• W3022289501 cites W2048646541 @default.
• W3022289501 cites W2049839653 @default.
• W3022289501 cites W2052492339 @default.
• W3022289501 cites W2054861424 @default.
• W3022289501 cites W2060065070 @default.
• W3022289501 cites W2064969549 @default.
• W3022289501 cites W2066665572 @default.
• W3022289501 cites W2067174909 @default.
• W3022289501 cites W2081046982 @default.
• W3022289501 cites W2084482408 @default.
• W3022289501 cites W2085601841 @default.
• W3022289501 cites W2087217881 @default.
• W3022289501 cites W2095078840 @default.
• W3022289501 cites W2098906326 @default.
• W3022289501 cites W2103325328 @default.
• W3022289501 cites W2106478835 @default.
• W3022289501 cites W2117641249 @default.
• W3022289501 cites W2131288855 @default.
• W3022289501 cites W2155552623 @default.
• W3022289501 cites W2161616648 @default.
• W3022289501 cites W2221756059 @default.
• W3022289501 cites W2298336203 @default.
• W3022289501 cites W2313116527 @default.
• W3022289501 cites W2332712348 @default.
• W3022289501 cites W2346206575 @default.
• W3022289501 cites W2466333954 @default.
• W3022289501 cites W2487837464 @default.
• W3022289501 cites W2785884569 @default.
• W3022289501 cites W2786469974 @default.
• W3022289501 cites W2796260285 @default.
• W3022289501 cites W2951377435 @default.
• W3022289501 cites W2967921964 @default.
• W3022289501 cites W2994851017 @default.
• W3022289501 cites W3022862968 @default.
• W3022289501 doi "https://doi.org/10.1101/2020.04.28.058271" @default.
• W3022289501 hasPublicationYear "2020" @default.
• W3022289501 type Work @default.
• W3022289501 sameAs 3022289501 @default.
• W3022289501 citedByCount "1" @default.
• W3022289501 countsByYear W30222895012020 @default.
• W3022289501 crossrefType "posted-content" @default.
• W3022289501 hasAuthorship W3022289501A5045387880 @default.
• W3022289501 hasAuthorship W3022289501A5046367313 @default.
• W3022289501 hasAuthorship W3022289501A5050443876 @default.
• W3022289501 hasAuthorship W3022289501A5054954864 @default.
• W3022289501 hasAuthorship W3022289501A5077468388 @default.
• W3022289501 hasAuthorship W3022289501A5078936621 @default.
• W3022289501 hasAuthorship W3022289501A5087286790 @default.
• W3022289501 hasBestOaLocation W30222895011 @default.
• W3022289501 hasConcept C104317684 @default.
• W3022289501 hasConcept C105580179 @default.
• W3022289501 hasConcept C106774688 @default.
• W3022289501 hasConcept C107824862 @default.
• W3022289501 hasConcept C114847915 @default.
• W3022289501 hasConcept C153957851 @default.
• W3022289501 hasConcept C176990463 @default.
• W3022289501 hasConcept C185581394 @default.
• W3022289501 hasConcept C185592680 @default.
• W3022289501 hasConcept C203353237 @default.
• W3022289501 hasConcept C38062823 @default.
• W3022289501 hasConcept C54355233 @default.
• W3022289501 hasConcept C552990157 @default.
• W3022289501 hasConcept C55334214 @default.
• W3022289501 hasConcept C67705224 @default.
• W3022289501 hasConcept C67905577 @default.
• W3022289501 hasConcept C86803240 @default.
• W3022289501 hasConcept C88478588 @default.
• W3022289501 hasConcept C96267730 @default.
• W3022289501 hasConceptScore W3022289501C104317684 @default.
• W3022289501 hasConceptScore W3022289501C105580179 @default.
• W3022289501 hasConceptScore W3022289501C106774688 @default.
• W3022289501 hasConceptScore W3022289501C107824862 @default.
• W3022289501 hasConceptScore W3022289501C114847915 @default.
• W3022289501 hasConceptScore W3022289501C153957851 @default.
• W3022289501 hasConceptScore W3022289501C176990463 @default.
• W3022289501 hasConceptScore W3022289501C185581394 @default.
• W3022289501 hasConceptScore W3022289501C185592680 @default.
• W3022289501 hasConceptScore W3022289501C203353237 @default.
• W3022289501 hasConceptScore W3022289501C38062823 @default.

• next