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• W3022312892 abstract "Activation of the cdc2 protein kinase at different stages of the cell cycle is regulated by post-translational modifications and interactions with cyclins. We show that in vitro translated human cdc2 binds very poorly to A and B cyclins, unless it has been preincubated with a Xenopus egg extract. This results in the phosphorylation of cdc2 which allows binding to cyclins. The replacement of Thr161, a residue conserved and phosphorylated in other protein kinases, with valine inhibits cdc2 association with A and B cyclins. In addition, mutations in the amino-terminus of cdc2 and within the conserved 'PSTAIR' region strongly inhibit binding. The Thr161Val mutation causes a lethal phenotype in the fission yeast Schizosaccharomyces pombe, while replacement of Thr161 with glutamic acid, potentially mimicking phosphorylation, causes uncoordination of mitosis and multiple cytokinesis. These results suggest that a threonine phosphorylation/dephosphorylation cycle is involved in regulating cdc2 function." @default.
• W3022312892 created "2020-05-13" @default.
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• W3022312892 date "1991-11-01" @default.
• W3022312892 modified "2023-10-01" @default.
• W3022312892 title "cdc2 phosphorylation is required for its interaction with cyclin." @default.
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• W3022312892 doi "https://doi.org/10.1002/j.1460-2075.1991.tb04895.x" @default.
• W3022312892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/453057" @default.
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