FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022318880> ?p ?o ?g. }

• W3022318880 abstract "Abstract Background Leptospirosis is a potentially fatal zoonosis. It can cause a wide range of symptoms, including diffuse alveolar haemorrhage which occurs in a minority of cases but carries a mortality of over 70%. These patients may present with severe acute respiratory failure. The differential diagnosis for diffuse alveolar haemorrhage is broad whereas prompt diagnosis and treatment can be lifesaving. Case presentation A 20-year-old previously fit and well trout farm worker presented with a 3-day history of malaise, fevers, diarrhoea, vomiting and jaundice. He developed haemoptysis, severe headaches, neck stiffness and photophobia on the day of emergency admission. He was anaemic and thrombocytopenic. Anuric acute kidney injury (urea 32, creat 507) required immediate haemofiltration. In view of progressive respiratory failure with four-quadrant lung infiltrates on imaging, he was given broad spectrum antibiotics and pulsed methylprednisolone empirically, in case of a vasculitic pulmonary-renal presentation. He was intubated within 48 h of admission. Despite attempted protective ventilatory management, he remained hypoxaemic and developed pneumomediastinum. He was retrieved to a specialist cardiorespiratory intensive care unit on femoro-femoral mobile VV-ECMO. Three days from admission, results showed positive Leptospira IgM and real-time PCR. Serial bronchoscopies showed old and fresh clots, but not the classical progressive late red tinge of the returned lavage fluid. After eight days, VV-ECMO was weaned, he was extubated three days later, and made a full recovery. At 9 months follow-up, he was clinically better, with resolution of the CT scan findings and near normal lung function, albeit with low normal gas transfer. Conclusions Leptospirosis is a rare but important differential to be considered in diffuse alveolar haemorrhage presenting to the ICU, especially in young males. A thorough history for occupational or recreational risk factors may offer the diagnostic clue. Most patients recover fully with antibiotics. However, resulting acute severe respiratory failure can ensue. In this situation, early consideration for respiratory ECMO support offers time for clearance of endobronchial clot, parenchymal recovery, and prevention of ventilator-induced lung injury. Steroids have no clear evidence but may be used to avoid delay in treating suspected vasculitic or autoimmune causes of diffuse alveolar haemorrhage." @default.
• W3022318880 created "2020-05-13" @default.
• W3022318880 creator A5006489109 @default.
• W3022318880 creator A5022810417 @default.
• W3022318880 creator A5039873138 @default.
• W3022318880 creator A5048484797 @default.
• W3022318880 date "2020-04-26" @default.
• W3022318880 modified "2023-10-17" @default.
• W3022318880 title "Leptospirosis as an important differential of pulmonary haemorrhage on the intensive care unit: a case managed with VV-ECMO" @default.
• W3022318880 cites W1492589077 @default.
• W3022318880 cites W1753494396 @default.
• W3022318880 cites W1909511714 @default.
• W3022318880 cites W1975646696 @default.
• W3022318880 cites W1993831309 @default.
• W3022318880 cites W1994052153 @default.
• W3022318880 cites W2000010134 @default.
• W3022318880 cites W2006364884 @default.
• W3022318880 cites W2012707107 @default.
• W3022318880 cites W2017146148 @default.
• W3022318880 cites W2022913623 @default.
• W3022318880 cites W2044917417 @default.
• W3022318880 cites W2058298839 @default.
• W3022318880 cites W2075710246 @default.
• W3022318880 cites W2139568408 @default.
• W3022318880 cites W2152164461 @default.
• W3022318880 cites W2159128934 @default.
• W3022318880 cites W2161879030 @default.
• W3022318880 cites W2313757836 @default.
• W3022318880 cites W2337916369 @default.
• W3022318880 cites W2593282126 @default.
• W3022318880 cites W2607950536 @default.
• W3022318880 cites W2761216930 @default.
• W3022318880 cites W2765916694 @default.
• W3022318880 cites W2999902147 @default.
• W3022318880 cites W4211105424 @default.
• W3022318880 doi "https://doi.org/10.1186/s40560-020-00447-2" @default.
• W3022318880 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7183660" @default.
• W3022318880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32351698" @default.
• W3022318880 hasPublicationYear "2020" @default.
• W3022318880 type Work @default.
• W3022318880 sameAs 3022318880 @default.
• W3022318880 citedByCount "7" @default.
• W3022318880 countsByYear W30223188802021 @default.
• W3022318880 countsByYear W30223188802022 @default.
• W3022318880 countsByYear W30223188802023 @default.
• W3022318880 crossrefType "journal-article" @default.
• W3022318880 hasAuthorship W3022318880A5006489109 @default.
• W3022318880 hasAuthorship W3022318880A5022810417 @default.
• W3022318880 hasAuthorship W3022318880A5039873138 @default.
• W3022318880 hasAuthorship W3022318880A5048484797 @default.
• W3022318880 hasBestOaLocation W30223188801 @default.
• W3022318880 hasConcept C141071460 @default.
• W3022318880 hasConcept C177713679 @default.
• W3022318880 hasConcept C2776376669 @default.
• W3022318880 hasConcept C2776888751 @default.
• W3022318880 hasConcept C2781137159 @default.
• W3022318880 hasConcept C36454342 @default.
• W3022318880 hasConcept C71924100 @default.
• W3022318880 hasConceptScore W3022318880C141071460 @default.
• W3022318880 hasConceptScore W3022318880C177713679 @default.
• W3022318880 hasConceptScore W3022318880C2776376669 @default.
• W3022318880 hasConceptScore W3022318880C2776888751 @default.
• W3022318880 hasConceptScore W3022318880C2781137159 @default.
• W3022318880 hasConceptScore W3022318880C36454342 @default.
• W3022318880 hasConceptScore W3022318880C71924100 @default.
• W3022318880 hasIssue "1" @default.
• W3022318880 hasLocation W30223188801 @default.
• W3022318880 hasLocation W30223188802 @default.
• W3022318880 hasLocation W30223188803 @default.
• W3022318880 hasLocation W30223188804 @default.
• W3022318880 hasLocation W30223188805 @default.
• W3022318880 hasOpenAccess W3022318880 @default.
• W3022318880 hasPrimaryLocation W30223188801 @default.
• W3022318880 hasRelatedWork W1506200166 @default.
• W3022318880 hasRelatedWork W1995515455 @default.
• W3022318880 hasRelatedWork W2048182022 @default.
• W3022318880 hasRelatedWork W2080531066 @default.
• W3022318880 hasRelatedWork W2604872355 @default.
• W3022318880 hasRelatedWork W2748952813 @default.
• W3022318880 hasRelatedWork W2899084033 @default.
• W3022318880 hasRelatedWork W3031052312 @default.
• W3022318880 hasRelatedWork W3032375762 @default.
• W3022318880 hasRelatedWork W3108674512 @default.
• W3022318880 hasVolume "8" @default.
• W3022318880 isParatext "false" @default.
• W3022318880 isRetracted "false" @default.
• W3022318880 magId "3022318880" @default.
• W3022318880 workType "article" @default.