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- W3022332604 abstract "Properties of a virus, frog virus 1 (FV 1), isolated from plaques appearing in uninoculated frog kidney cell monolayers were studied. The virus multiplied at 24 ° in frog, fish, chick embryo, and hamster cell monolayers with cytopathology resulting in cell death. Although each cell system could be used for plaque assay the efficiency of plating was higher (10- to 100-fold) in chick embryo and hamster cells. Growth curves in cultured cells from both poikilothermic and homothermic animals were similar with a latent period between 6 and 10 hours. Most of the virus (50–99%) remained cell-associated. Virus multiplication was temperature dependent. At 33 ° plaques did not develop and little or no infectious virus was produced although adsorption and penetration occurred. Virus multiplication ceased when infected cultures were removed from 24 ° to 33 ° at any time during the growth cycle, a phenomenon suggesting that virus maturation was thermosensitive. The site of virus synthesis appeared to be the cell cytoplasm where DNA, identified by cytochemical stains and isotope incorporation, accumulated during infection. Infectivity was lost by exposure of virus to lipid solvents or to pH 3.0. It was stable to storage at low temperature (−20 ° to −60 °) but was rapidly inactivated at 50 °. Additional virus isolations were made from spontaneously degenerating frog kidney cell cultures and from homogenates of frog livers and frog renal tumors (Lucké adenocarcinoma). There was no correlation between the presence of intranuclear inclusions or virus particles (as observed by light and electron microscopy) and the ability to isolate virus from tumor homogenates. Comparative tests showed no distinguishing differences between properties of an isolate from a Lucké tumor, FV 3, and FV 1. The results are discussed as they relate to a viral etiology of the Lucké tumor." @default.
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- W3022332604 title "Viruses and renal carcinoma of Rana pipiens" @default.
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- W3022332604 doi "https://doi.org/10.1016/0042-6822(66)90203-0" @default.
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