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• W3022333404 endingPage "107612" @default.
• W3022333404 startingPage "107612" @default.
• W3022333404 abstract "Summary Eukaryotic genomes are almost entirely transcribed by RNA polymerase II. Consequently, the transcription of long noncoding RNAs often overlaps with coding gene promoters, triggering potential gene repression through a poorly characterized mechanism of transcription interference. Here, we propose a comprehensive model of chromatin-based transcription interference in Saccharomyces cerevisiae (S. cerevisiae). By using a noncoding transcription-inducible strain, we analyze the relationship between antisense elongation and coding sense repression, nucleosome occupancy, and transcription-associated histone modifications using near-base pair resolution techniques. We show that antisense noncoding transcription leads to the deacetylation of a subpopulation of −1/+1 nucleosomes associated with increased H3K36me3. Reduced acetylation results in the decreased binding of the RSC chromatin remodeler at −1/+1 nucleosomes and subsequent sliding into the nucleosome-depleted region hindering pre-initiation complex association. Finally, we extend our model by showing that natural antisense noncoding transcription significantly represses ∼20% of S. cerevisiae genes through this chromatin-based transcription interference mechanism." @default.
• W3022333404 created "2020-05-13" @default.
• W3022333404 creator A5013411826 @default.
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• W3022333404 creator A5073233728 @default.
• W3022333404 date "2020-05-01" @default.
• W3022333404 modified "2023-10-12" @default.
• W3022333404 title "Fine Chromatin-Driven Mechanism of Transcription Interference by Antisense Noncoding Transcription" @default.
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• W3022333404 cites W1937291806 @default.
• W3022333404 cites W1956016540 @default.
• W3022333404 cites W1963604994 @default.
• W3022333404 cites W1968055625 @default.
• W3022333404 cites W1968112541 @default.
• W3022333404 cites W1969228261 @default.
• W3022333404 cites W1974426680 @default.
• W3022333404 cites W1974595249 @default.
• W3022333404 cites W1979249520 @default.
• W3022333404 cites W1984436755 @default.
• W3022333404 cites W1987152324 @default.
• W3022333404 cites W1992656378 @default.
• W3022333404 cites W1995391727 @default.
• W3022333404 cites W2000629769 @default.
• W3022333404 cites W2007844697 @default.
• W3022333404 cites W2008616402 @default.
• W3022333404 cites W2017550851 @default.
• W3022333404 cites W2025836692 @default.
• W3022333404 cites W2029291109 @default.
• W3022333404 cites W2030764375 @default.
• W3022333404 cites W2034340491 @default.
• W3022333404 cites W2036193154 @default.
• W3022333404 cites W2037429489 @default.
• W3022333404 cites W2040378600 @default.
• W3022333404 cites W2055906772 @default.
• W3022333404 cites W2062669590 @default.
• W3022333404 cites W2067393096 @default.
• W3022333404 cites W2068190648 @default.
• W3022333404 cites W2072887529 @default.
• W3022333404 cites W2073029061 @default.
• W3022333404 cites W2076825429 @default.
• W3022333404 cites W2083174529 @default.
• W3022333404 cites W2092716906 @default.
• W3022333404 cites W2095881412 @default.
• W3022333404 cites W2125433175 @default.
• W3022333404 cites W2126188271 @default.
• W3022333404 cites W2134903961 @default.
• W3022333404 cites W2136457795 @default.
• W3022333404 cites W2136623765 @default.
• W3022333404 cites W2146300258 @default.
• W3022333404 cites W2149993601 @default.
• W3022333404 cites W2150075314 @default.
• W3022333404 cites W2155277330 @default.
• W3022333404 cites W2166593443 @default.
• W3022333404 cites W2166612340 @default.
• W3022333404 cites W2166810745 @default.
• W3022333404 cites W2167840211 @default.
• W3022333404 cites W2170551349 @default.
• W3022333404 cites W2170728895 @default.
• W3022333404 cites W2171432823 @default.
• W3022333404 cites W2172368992 @default.
• W3022333404 cites W2173031340 @default.
• W3022333404 cites W2295180956 @default.
• W3022333404 cites W2341539131 @default.
• W3022333404 cites W2478629008 @default.
• W3022333404 cites W2480728253 @default.
• W3022333404 cites W2504339242 @default.
• W3022333404 cites W2506779270 @default.
• W3022333404 cites W2559450437 @default.
• W3022333404 cites W2587668290 @default.
• W3022333404 cites W2604467403 @default.
• W3022333404 cites W2606460136 @default.
• W3022333404 cites W2618569629 @default.
• W3022333404 cites W2763907932 @default.
• W3022333404 cites W2767530502 @default.
• W3022333404 cites W2782638879 @default.
• W3022333404 cites W2787286188 @default.
• W3022333404 cites W2791548497 @default.
• W3022333404 cites W2796205786 @default.
• W3022333404 cites W2810498756 @default.
• W3022333404 cites W2831181062 @default.
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• W3022333404 doi "https://doi.org/10.1016/j.celrep.2020.107612" @default.
• W3022333404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32375040" @default.
• W3022333404 hasPublicationYear "2020" @default.
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• W3022333404 citedByCount "21" @default.

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