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- W3022342813 abstract "Publisher SummaryThis chapter focuses on the physical and biological properties of Clostridium perfringens β-toxin. The differential production of the major toxins is used to classify the bacterium into five toxigenic types, A, B, C, D and E. It is now recognized as the major virulence determinant in enterotoxaemia and necrotic enteritis of a variety of animal species, particularly sheep, lambs, calves, piglets, and fowl. It is also known to cause a similar disease in humans called enteritis necroticans or pig-bel, which is endemic in the Highlands of Papua New Guinea. The conditions leading to the onset of the human disease are curious, and are associated with the consumption of under-cooked meat contaminated with C. perfringens type C spores by individuals who have a reduced level of intestinal proteases resulting from malnourishment, or who consume other foods containing protease inhibitors. The diseases in both humans and animals can be controlled effectively by the administration of β-toxoid, prepared from C. perfringens type C culture filtrates." @default.
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- W3022342813 date "1997-01-01" @default.
- W3022342813 modified "2023-09-27" @default.
- W3022342813 title "The Clostridium perfringens β-toxin" @default.
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- W3022342813 doi "https://doi.org/10.1016/b978-012595020-6/50017-6" @default.
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