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- W3022343152 abstract "Conventional chemotherapy is effective for metastatic tumors widely present in colorectal cancer patients; however, chemotherapy may cause severe systemic toxicity due to a lack of specificity towards cancer cells. Effective delivery systems that can enhance targeted drug delivery to the desired tumor site and simultaneously protect the activity of drugs are in high demand. To that end, this study developed chitosan-based polyelectrolyte complexes (PECs) with the orientation of superparamagnetic nanoparticles, which enables the targeting delivery of the first-line model drug irinotecan (IRT) to the tumor area under a magnetic field. Colloidal PECs were mildly and facilely fabricated with chitosan and poly(glutamic acid) (PGA) via an all-in-water process, excluding the use of any potentially toxic chemicals. Iso-dispersed superparamagnetic Fe3O4 nanoparticles with relatively small particle diameters (~10 nm) were embedded into the IRT-loaded nano-PECs. The optimized nano-PECs showed high drug encapsulation capacity and improved anti-colon cancer cell efficacy compared with the free drug. Furthermore, the magnetic nano-PECs exhibited effective internalization by colon tumor cells, and favorable tumor-targeting ability was demonstrated via in vivo biodistribution study. Therefore, this magnetic targeted drug delivery nano-PECs system provides a promising platform to overcome the side effects of conventional chemotherapy for colorectal cancer." @default.
- W3022343152 created "2020-05-13" @default.
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- W3022343152 date "2020-06-01" @default.
- W3022343152 modified "2023-10-14" @default.
- W3022343152 title "Superparamagnetic chitosan nanocomplexes for colorectal tumor-targeted delivery of irinotecan" @default.
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- W3022343152 doi "https://doi.org/10.1016/j.ijpharm.2020.119394" @default.
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