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- W3022343758 abstract "What is known and objective Pazopanib is a tyrosine kinase inhibitor with hyperglycaemia as a known adverse event, but case reports of severe hyperglycaemia are exceptional. We report a case of severe hyperglycaemia following pazopanib administration in a patient with metastatic renal cell carcinoma. Case summary Severe hyperglycaemia developed in a patient one month following initiation of pazopanib therapy. As drug-drug-gene interactions may lead to hyperglycaemia, pharmacogenetic assessment was requested. The obtained findings indicated intermediate function of both OATP1B1 and P-glycoprotein transporters, which may cause prolonged pazopanib bioavailability and increased toxicity. Pazopanib was discontinued and, following patient recovery, was reintroduced at a lower dose. What is new and Conclusion The pharmacogenetic profiling of the patient on polypharmacy enabled better management of pazopanib therapy." @default.
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- W3022343758 date "2020-05-05" @default.
- W3022343758 modified "2023-10-16" @default.
- W3022343758 title "Severe hyperglycaemia following pazopanib treatment: The role of drug‐drug‐gene interactions in a patient with metastatic renal cell carcinoma—A case report" @default.
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- W3022343758 doi "https://doi.org/10.1111/jcpt.13160" @default.
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