Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022356039> ?p ?o ?g. }
- W3022356039 endingPage "e1008521" @default.
- W3022356039 startingPage "e1008521" @default.
- W3022356039 abstract "Zika virus (ZIKV) infection may lead to congenital microcephaly and pregnancy loss in pregnant women. In the context of pregnancy, folic acid (FA) supplementation may reduce the risk of abnormal pregnancy outcomes. Intriguingly, FA may have a beneficial effect on the adverse pregnancy outcomes associated with ZIKV infection. Here, we show that FA inhibits ZIKV replication in human umbilical vein endothelial cells (HUVECs) and a cell culture model of blood-placental barrier (BPB). The inhibitory effect of FA against ZIKV infection is associated with FRα-AMPK signaling. Furthermore, treatment with FA reduces pathological features in the placenta, number of fetal resorptions, and stillbirths in two mouse models of in utero ZIKV transmission. Mice with FA treatment showed lower viral burden and better prognostic profiles in the placenta including reduced inflammatory response, and enhanced integrity of BPB. Overall, our findings suggest the preventive role of FA supplementation in ZIKV-associated abnormal pregnancy and warrant nutritional surveillance to evaluate maternal FA status in areas with active ZIKV transmission." @default.
- W3022356039 created "2020-05-13" @default.
- W3022356039 creator A5005108655 @default.
- W3022356039 creator A5010435147 @default.
- W3022356039 creator A5038207357 @default.
- W3022356039 creator A5049449624 @default.
- W3022356039 creator A5062338617 @default.
- W3022356039 date "2020-05-11" @default.
- W3022356039 modified "2023-10-17" @default.
- W3022356039 title "Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice" @default.
- W3022356039 cites W1524567271 @default.
- W3022356039 cites W1597619535 @default.
- W3022356039 cites W1700743858 @default.
- W3022356039 cites W1873839240 @default.
- W3022356039 cites W1963776452 @default.
- W3022356039 cites W1967725380 @default.
- W3022356039 cites W1975029215 @default.
- W3022356039 cites W1977310811 @default.
- W3022356039 cites W1996052643 @default.
- W3022356039 cites W2009408552 @default.
- W3022356039 cites W2049309713 @default.
- W3022356039 cites W2053366220 @default.
- W3022356039 cites W2061164005 @default.
- W3022356039 cites W2064381749 @default.
- W3022356039 cites W2064672117 @default.
- W3022356039 cites W2078067802 @default.
- W3022356039 cites W2090427940 @default.
- W3022356039 cites W2091859654 @default.
- W3022356039 cites W2092227991 @default.
- W3022356039 cites W2098453804 @default.
- W3022356039 cites W2109920630 @default.
- W3022356039 cites W2110466003 @default.
- W3022356039 cites W2113328354 @default.
- W3022356039 cites W2121836743 @default.
- W3022356039 cites W2137816493 @default.
- W3022356039 cites W2154082610 @default.
- W3022356039 cites W2222113668 @default.
- W3022356039 cites W2283927707 @default.
- W3022356039 cites W2295245778 @default.
- W3022356039 cites W2300936249 @default.
- W3022356039 cites W2339816627 @default.
- W3022356039 cites W2343000142 @default.
- W3022356039 cites W2384699986 @default.
- W3022356039 cites W2406009021 @default.
- W3022356039 cites W2476820040 @default.
- W3022356039 cites W2493663572 @default.
- W3022356039 cites W2522192606 @default.
- W3022356039 cites W2524063359 @default.
- W3022356039 cites W2556343293 @default.
- W3022356039 cites W2563819932 @default.
- W3022356039 cites W2575440932 @default.
- W3022356039 cites W2589253427 @default.
- W3022356039 cites W2613031442 @default.
- W3022356039 cites W2617666130 @default.
- W3022356039 cites W2752757076 @default.
- W3022356039 cites W2754579053 @default.
- W3022356039 cites W2767916436 @default.
- W3022356039 cites W2771128043 @default.
- W3022356039 cites W2783319844 @default.
- W3022356039 cites W2785386287 @default.
- W3022356039 cites W2793055876 @default.
- W3022356039 cites W2797004612 @default.
- W3022356039 cites W2895587115 @default.
- W3022356039 cites W2919849181 @default.
- W3022356039 cites W4205879768 @default.
- W3022356039 cites W4211210279 @default.
- W3022356039 cites W60021579 @default.
- W3022356039 doi "https://doi.org/10.1371/journal.ppat.1008521" @default.
- W3022356039 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7241851" @default.
- W3022356039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32392268" @default.
- W3022356039 hasPublicationYear "2020" @default.
- W3022356039 type Work @default.
- W3022356039 sameAs 3022356039 @default.
- W3022356039 citedByCount "9" @default.
- W3022356039 countsByYear W30223560392020 @default.
- W3022356039 countsByYear W30223560392021 @default.
- W3022356039 countsByYear W30223560392022 @default.
- W3022356039 crossrefType "journal-article" @default.
- W3022356039 hasAuthorship W3022356039A5005108655 @default.
- W3022356039 hasAuthorship W3022356039A5010435147 @default.
- W3022356039 hasAuthorship W3022356039A5038207357 @default.
- W3022356039 hasAuthorship W3022356039A5049449624 @default.
- W3022356039 hasAuthorship W3022356039A5062338617 @default.
- W3022356039 hasBestOaLocation W30223560391 @default.
- W3022356039 hasConcept C151730666 @default.
- W3022356039 hasConcept C159047783 @default.
- W3022356039 hasConcept C172680121 @default.
- W3022356039 hasConcept C187212893 @default.
- W3022356039 hasConcept C203014093 @default.
- W3022356039 hasConcept C2522874641 @default.
- W3022356039 hasConcept C2776185481 @default.
- W3022356039 hasConcept C2776395126 @default.
- W3022356039 hasConcept C2776953305 @default.
- W3022356039 hasConcept C2777053367 @default.
- W3022356039 hasConcept C2779234561 @default.
- W3022356039 hasConcept C2779343474 @default.
- W3022356039 hasConcept C2780568436 @default.
- W3022356039 hasConcept C54355233 @default.