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• W3022365747 abstract "Background Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in affluent countries. Recent studies have reported that circular RNAs (circRNAs) are important regulators of hepatic steatosis. However, the role and mechanism of circRNA in NAFLD are poorly understood. Methods Through NAFLD-related circRNA microarrays, we used real-time quantitative reverse transcription-polymerase chain reaction to screen circScd1 levels in control and test groups of mice fed a high-fat diet. RNA interference and overexpression plasmid vectors were used to manipulate the expression of circScd1, and the biological effects were evaluated by oil red staining, triglyceride detection, and western blot analysis. Results CircScd1 expression was significantly lower in NAFLD tissues than in control tissues. Moreover, overexpression of circScd1 significantly inhibited the formation of lipid droplets. Western blot analyses showed that the protein levels of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5) were significantly increased. However, knockdown of circScd1 significantly promoted the degree of hepatocellular lipidosis and reduced the expression levels of JAK2 and STAT5. Conclusions Aberrant expression of circScd1 affects the extent of hepatocellular lipidosis in NAFLD and promotes fatty liver disease via the JAK2/STAT5 pathway." @default.
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• W3022365747 date "2018-06-01" @default.
• W3022365747 modified "2023-09-23" @default.
• W3022365747 title "IDDF2018-ABS-0074 CIRCSCD1 promotes fatty liver disease via the janus kinase 2/signal transducer and activator of transcription 5 pathway" @default.
• W3022365747 doi "https://doi.org/10.1136/gutjnl-2018-iddfabstracts.46" @default.
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