Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022369570> ?p ?o ?g. }
- W3022369570 endingPage "3362" @default.
- W3022369570 startingPage "3347" @default.
- W3022369570 abstract "Temozolomide (TMZ) is the first-line chemotherapeutic option to treat glioma; however, its efficacy and clinical application are limited by its drug resistance properties. Polo-like kinase 1 (PLK1)-targeted therapy causes G2/M arrest and increases the sensitivity of glioma to TMZ. Therefore, to limit TMZ resistance in glioma, an angiopep-2 (A2)-modified polymeric micelle (A2PEC) embedded with TMZ and a small interfering RNA (siRNA) targeting PLK1 (siPLK1) was developed (TMZ-A2PEC/siPLK).TMZ was encapsulated by A2-PEG-PEI-PCL (A2PEC) through the hydrophobic interaction, and siPLK1 was complexed with the TMZ-A2PEC through electrostatic interaction. Then, an angiopep-2 (A2) modified polymeric micelle (A2PEC) embedding TMZ and siRNA targeting polo-like kinase 1 (siPLK1) was developed (TMZ-A2PEC/siPLK).In vitro experiments indicated that TMZ-A2PEC/siPLK effectively enhanced the cellular uptake of TMZ and siPLK1 and resulted in significant cell apoptosis and cytotoxicity of glioma cells. In vivo experiments showed that glioma growth was inhibited, and the survival time of the animals was prolonged remarkably after TMZ-A2PEC/siPLK1 was injected via their tail vein.The results demonstrate that the combination of TMZ and siPLK1 in A2PEC could enhance the efficacy of TMZ in treating glioma." @default.
- W3022369570 created "2020-05-13" @default.
- W3022369570 creator A5000838361 @default.
- W3022369570 creator A5001873050 @default.
- W3022369570 creator A5002442029 @default.
- W3022369570 creator A5028256671 @default.
- W3022369570 creator A5031662825 @default.
- W3022369570 creator A5049655034 @default.
- W3022369570 creator A5060329178 @default.
- W3022369570 creator A5078220885 @default.
- W3022369570 creator A5080228020 @default.
- W3022369570 creator A5089404504 @default.
- W3022369570 date "2020-05-01" @default.
- W3022369570 modified "2023-10-13" @default.
- W3022369570 title "<p>Combined Delivery of Temozolomide and siPLK1 Using Targeted Nanoparticles to Enhance Temozolomide Sensitivity in Glioma</p>" @default.
- W3022369570 cites W1767510440 @default.
- W3022369570 cites W1817360198 @default.
- W3022369570 cites W1901198588 @default.
- W3022369570 cites W1975776530 @default.
- W3022369570 cites W1976820765 @default.
- W3022369570 cites W1988816960 @default.
- W3022369570 cites W1989165356 @default.
- W3022369570 cites W1990074743 @default.
- W3022369570 cites W2008624144 @default.
- W3022369570 cites W2022605033 @default.
- W3022369570 cites W2032371417 @default.
- W3022369570 cites W2035853571 @default.
- W3022369570 cites W2042806249 @default.
- W3022369570 cites W2061543625 @default.
- W3022369570 cites W2062068877 @default.
- W3022369570 cites W2083416032 @default.
- W3022369570 cites W2121102974 @default.
- W3022369570 cites W2131411258 @default.
- W3022369570 cites W2133367407 @default.
- W3022369570 cites W2175107396 @default.
- W3022369570 cites W2313788377 @default.
- W3022369570 cites W2322916630 @default.
- W3022369570 cites W2328583575 @default.
- W3022369570 cites W2464405525 @default.
- W3022369570 cites W2467902526 @default.
- W3022369570 cites W2507962256 @default.
- W3022369570 cites W2552907949 @default.
- W3022369570 cites W2585444321 @default.
- W3022369570 cites W2587758675 @default.
- W3022369570 cites W2619196560 @default.
- W3022369570 cites W2771792994 @default.
- W3022369570 cites W2773307196 @default.
- W3022369570 cites W2783481949 @default.
- W3022369570 cites W2793282665 @default.
- W3022369570 cites W2793453538 @default.
- W3022369570 cites W2793508252 @default.
- W3022369570 cites W2793629808 @default.
- W3022369570 cites W2799819879 @default.
- W3022369570 cites W2804818197 @default.
- W3022369570 cites W2807711431 @default.
- W3022369570 cites W2807770298 @default.
- W3022369570 cites W2886446570 @default.
- W3022369570 cites W2886954940 @default.
- W3022369570 cites W2888668805 @default.
- W3022369570 cites W2888674289 @default.
- W3022369570 cites W2891163299 @default.
- W3022369570 cites W2901756866 @default.
- W3022369570 cites W2904297288 @default.
- W3022369570 cites W2905056664 @default.
- W3022369570 cites W2905703306 @default.
- W3022369570 cites W2906326387 @default.
- W3022369570 doi "https://doi.org/10.2147/ijn.s243878" @default.
- W3022369570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7229804" @default.
- W3022369570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32494134" @default.
- W3022369570 hasPublicationYear "2020" @default.
- W3022369570 type Work @default.
- W3022369570 sameAs 3022369570 @default.
- W3022369570 citedByCount "35" @default.
- W3022369570 countsByYear W30223695702020 @default.
- W3022369570 countsByYear W30223695702021 @default.
- W3022369570 countsByYear W30223695702022 @default.
- W3022369570 countsByYear W30223695702023 @default.
- W3022369570 crossrefType "journal-article" @default.
- W3022369570 hasAuthorship W3022369570A5000838361 @default.
- W3022369570 hasAuthorship W3022369570A5001873050 @default.
- W3022369570 hasAuthorship W3022369570A5002442029 @default.
- W3022369570 hasAuthorship W3022369570A5028256671 @default.
- W3022369570 hasAuthorship W3022369570A5031662825 @default.
- W3022369570 hasAuthorship W3022369570A5049655034 @default.
- W3022369570 hasAuthorship W3022369570A5060329178 @default.
- W3022369570 hasAuthorship W3022369570A5078220885 @default.
- W3022369570 hasAuthorship W3022369570A5080228020 @default.
- W3022369570 hasAuthorship W3022369570A5089404504 @default.
- W3022369570 hasBestOaLocation W30223695701 @default.
- W3022369570 hasConcept C150903083 @default.
- W3022369570 hasConcept C185592680 @default.
- W3022369570 hasConcept C190283241 @default.
- W3022369570 hasConcept C207001950 @default.
- W3022369570 hasConcept C22615655 @default.
- W3022369570 hasConcept C2777389519 @default.
- W3022369570 hasConcept C2778227246 @default.
- W3022369570 hasConcept C502942594 @default.
- W3022369570 hasConcept C54009773 @default.