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- W3022376061 startingPage "3209" @default.
- W3022376061 abstract "Storage lesion is a critical issue facing transfusion treatments, and it adversely affects the quality and viability of stored red blood cells (RBCs). RBC deformability is a key indicator of cell health. Deformability measurements of each RBC unit are a key challenge in transfusion medicine research and clinical haematology. In this paper, a numerical study, inspired from the previous research for RBC deformability and morphology predictions, is conducted for the first time, to investigate the deformability and morphology characteristics of RBCs undergoing storage lesion. This study investigates the evolution of the cell shape factor, elongation index and membrane spicule details, where applicable, of discocyte, echinocyte I, echinocyte II, echinocyte III and sphero-echinocyte morphologies during 42 days of in-vitro storage at 4 °C in saline-adenine-glucose-mannitol (SAGM). Computer simulations were performed to investigate the influence of storage lesion-induced membrane structural defects on cell deformability and its recoverability during optical tweezers stretching deformations. The predicted morphology and deformability indicate decreasing quality and viability of stored RBCs undergoing storage lesion. The loss of membrane structural integrity due to the storage lesion further degrades the cell deformability and recoverability during mechanical deformations. This numerical approach provides a potential framework to study the RBC deformation characteristics under varying pathophysiological conditions for better diagnostics and treatments." @default.
- W3022376061 created "2020-05-13" @default.
- W3022376061 creator A5002881487 @default.
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- W3022376061 creator A5033093165 @default.
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- W3022376061 creator A5085498297 @default.
- W3022376061 date "2020-05-04" @default.
- W3022376061 modified "2023-09-24" @default.
- W3022376061 title "Modelling of Red Blood Cell Morphological and Deformability Changes during In-Vitro Storage" @default.
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- W3022376061 doi "https://doi.org/10.3390/app10093209" @default.
- W3022376061 hasPublicationYear "2020" @default.
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