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• W3022378002 abstract "Exposure to ultravioletradiation (UVR) has been shown to cause cellular damage in cyanobacteria. Inresponse to UVR exposure, some cyanobacteria produce scytonemin, anindole-alkaloid sunscreen capable of absorbing long-wavelength UVA radiation.Previous genomic and transcriptomic analyses have determined that theproduction of scytonemin is controlled by a two-component regulatory system(TCRS), encoded by Npun_F1277 and Npun_F1278 in the cyanobacterium Nostoc punctiforme ATCC 29133. This TCRSis thought to not only regulate scytonemin biosynthesis, but also otherresponses to light and UVR stimuli. To better understand the functionality ofthe sensor kinase (SK) Npun_F1277 and to determine if it could activatealternative UVR protection pathways, the SK was expressed in Escherichia coli. The first objective ofthis study was to observe and quantify the level of fitness conferred to E. coli expressing Npun_F1277 from N. punctiforme (strain SKE) when exposed to white light, UVA, and UVB stress. Resultsfrom these experiments do not indicate that expression of the N. punctiformeSK conferred an advantage to E. coli under white light, UVA, or UVBstress based on growth alone. Therefore, the second objective was to study theexpression of regulatory genes, such as response regulators, in E. colithat are homologs to those associated with the SK Npun_F1277 in N. punctiformeusing quantitative-PCR. Expression of the selected genes was measuredfollowing exposure to white light and UVA after 30 and 60 minutes as well asUVB after 15 and 30 minutes. Comparison of SKE to empty-vector (EV) controlcells exposed to the same stress showed that there were significant changes inthe expression of important regulatory genes (e.g. recA, spoT, relA) inthe SKE strain. Moreover, when comparing SKE cells exposed to the sameconditions above to unstressed SKE cells, a similar result was seen for SKEcells exposed to UVA and UVB as was found in the studies comparing SKE to EVcells. These results suggest that the SK Npun_F1277 may play a role in multipledefense mechanisms of N. punctiformein addition to initiation of the scytonemin biosynthesis pathway." @default.
• W3022378002 created "2020-05-13" @default.
• W3022378002 creator A5077357689 @default.
• W3022378002 date "2020-04-28" @default.
• W3022378002 modified "2023-09-26" @default.
• W3022378002 title "Analysis of a Cyanobacterial UV-Sensitive Sensor Kinase Expressed in Escherichia coli" @default.
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• W3022378002 doi "https://doi.org/10.25394/pgs.12202271.v1" @default.
• W3022378002 hasPublicationYear "2020" @default.
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