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- W3022382479 abstract "The science of serology involves the detection of immune components in the blood, particularly serum. It is the presence of rabies-specific antibodies in serum or cerebrospinal fluid that indicates prior exposure to rabies virus antigens. The measurement of rabies virus specific antibodies is a useful tool for evaluating both the level of humoral immunity in vaccinated individuals and for diagnostic purposes in patients suspected of having rabies. Knowledge of the specific strengths, weaknesses, and limitations of the available methods enables the selection of the appropriate method and aids in the interpretation of the subsequent results. A variety of serological methods are developed for testing the presence of rabies virus antibodies. Numerous reports indicate that protection against rabies is dependent upon the presence of rabies virus neutralizing antibodies (RVNAs). Thus, assays to detect and quantify RVNAs, such as the rapid fluorescent focus inhibition test and the fluorescent antibody virus neutralization test, are the methods recommended for quantitation purposes in rabies serology. The laboratory materials, instruments and safety equipment available also must be considered when evaluating the assay to be used. Finally, it is critical to understand exactly which components will be measured in terms of the antibody response itself when choosing an appropriate assay for detection of rabies virus." @default.
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- W3022382479 date "2007-01-01" @default.
- W3022382479 modified "2023-09-23" @default.
- W3022382479 title "Rabies Serology" @default.
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- W3022382479 doi "https://doi.org/10.1016/b978-012369366-2/50013-0" @default.
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