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- W3022388632 abstract "Botulinum toxin, type B, was given intradermally for migraines of cervical origin. All study patients had cervical muscle spasm. This double-blind study follows up on prior open-label studies. 40 patients were entered. 16 each received intradermal botulinum toxin, type B, 2500 units and 5000 units, respectively. 8 patients received placebo. Intradermal toxin was given over the site of the greater and lesser occipital nerves on the side of predominant migraine headaches. After 1 month, all 8 placebo patients elected to receive 5000 units and be followed for 3 months. The migraine frequency and severity was assessed monthly at followup using headache diary cards. Both 2500 unit and 5000 unit dosing, compared to placebo, showed highly statistically significant reductions of migraine frequency as well as severity at the first time point (1 month after injection) and maintained at the last study visit, 3 months after intradermal botulinum toxin, type B. Headache reductions in frequency were p<.001 for both strengths of botulinum toxin, type B. Reductions in migraine severity continued at p<.01 and p<.02 [2500units and 5000 units, respectively] compared to placebo. All patients reported relief of muscle spasm over the entire course of the study. We conclude that intradermal administration of botulinum toxin, type B, reduced both frequency and severity of migraines of cervical origin. This new way of dosing botulinum toxin, type B, replicates and extends, in a double-blind fashion, our original open-label data with the same type of migraine headaches. Safety and tolerability of intradermal botulinum toxin, type B, are excellent. This dosing of botulinum toxin, type B, for migraines of cervical origin suggests mechanisms of action of the toxin that do not utilize motor nerve elements and may involve alterations in pain transmission pathways, as has been demonstrated in the case of glutamate, Substance P and CGRP release." @default.
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- W3022388632 date "2006-04-01" @default.
- W3022388632 modified "2023-10-14" @default.
- W3022388632 title "(841)" @default.
- W3022388632 doi "https://doi.org/10.1016/j.jpain.2006.01.243" @default.
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