Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022402577> ?p ?o ?g. }
- W3022402577 endingPage "194566" @default.
- W3022402577 startingPage "194566" @default.
- W3022402577 abstract "The ATP-dependent BAF chromatin remodeling complex plays a critical role in gene regulation by modulating chromatin architecture, and is frequently mutated in cancer. Indeed, subunits of the BAF complex are found to be mutated in >20% of human tumors. The mechanism by which BAF properly navigates chromatin is not fully understood, but is thought to involve a multivalent network of histone and DNA contacts. We previously identified a composite domain in the BRG1 ATPase subunit that is capable of associating with both histones and DNA in a multivalent manner. Mapping the DNA binding pocket revealed that it contains several cancer mutations. Here, we utilize SELEX-seq to investigate the DNA specificity of this composite domain and NMR spectroscopy and molecular modelling to determine the structural basis of DNA binding. Finally, we demonstrate that cancer mutations in this domain alter the mode of DNA association." @default.
- W3022402577 created "2020-05-13" @default.
- W3022402577 creator A5001747398 @default.
- W3022402577 creator A5026136298 @default.
- W3022402577 creator A5038917104 @default.
- W3022402577 creator A5044070375 @default.
- W3022402577 creator A5046533914 @default.
- W3022402577 creator A5058301775 @default.
- W3022402577 creator A5058932447 @default.
- W3022402577 creator A5067188352 @default.
- W3022402577 creator A5071802051 @default.
- W3022402577 date "2020-08-01" @default.
- W3022402577 modified "2023-10-17" @default.
- W3022402577 title "The molecular basis of selective DNA binding by the BRG1 AT-hook and bromodomain" @default.
- W3022402577 cites W1031578623 @default.
- W3022402577 cites W1548068969 @default.
- W3022402577 cites W1570257026 @default.
- W3022402577 cites W1721232948 @default.
- W3022402577 cites W1976499671 @default.
- W3022402577 cites W1980722147 @default.
- W3022402577 cites W1984249881 @default.
- W3022402577 cites W1984733368 @default.
- W3022402577 cites W1984793963 @default.
- W3022402577 cites W1986959387 @default.
- W3022402577 cites W2009826707 @default.
- W3022402577 cites W2010497399 @default.
- W3022402577 cites W2012627860 @default.
- W3022402577 cites W2021120490 @default.
- W3022402577 cites W2029667189 @default.
- W3022402577 cites W2030945287 @default.
- W3022402577 cites W2058902552 @default.
- W3022402577 cites W2065283382 @default.
- W3022402577 cites W2065426928 @default.
- W3022402577 cites W2067174909 @default.
- W3022402577 cites W2072547562 @default.
- W3022402577 cites W2074897214 @default.
- W3022402577 cites W2074974586 @default.
- W3022402577 cites W2080571195 @default.
- W3022402577 cites W2081693079 @default.
- W3022402577 cites W2082259010 @default.
- W3022402577 cites W2095512976 @default.
- W3022402577 cites W2096194359 @default.
- W3022402577 cites W2102499347 @default.
- W3022402577 cites W2106578635 @default.
- W3022402577 cites W2110251865 @default.
- W3022402577 cites W2114843025 @default.
- W3022402577 cites W2116101416 @default.
- W3022402577 cites W2118937292 @default.
- W3022402577 cites W2122344714 @default.
- W3022402577 cites W2123647733 @default.
- W3022402577 cites W2126888219 @default.
- W3022402577 cites W2132213868 @default.
- W3022402577 cites W2137511124 @default.
- W3022402577 cites W2139044006 @default.
- W3022402577 cites W2144727118 @default.
- W3022402577 cites W2144792857 @default.
- W3022402577 cites W2147946837 @default.
- W3022402577 cites W2149006664 @default.
- W3022402577 cites W2149441684 @default.
- W3022402577 cites W2153983456 @default.
- W3022402577 cites W2154019529 @default.
- W3022402577 cites W2161605421 @default.
- W3022402577 cites W2166755632 @default.
- W3022402577 cites W2169707043 @default.
- W3022402577 cites W2169821755 @default.
- W3022402577 cites W2173232888 @default.
- W3022402577 cites W2281392042 @default.
- W3022402577 cites W2315040414 @default.
- W3022402577 cites W2433523887 @default.
- W3022402577 cites W2734641630 @default.
- W3022402577 cites W2745343063 @default.
- W3022402577 cites W2784755083 @default.
- W3022402577 cites W2883217678 @default.
- W3022402577 cites W2895877323 @default.
- W3022402577 cites W2902716564 @default.
- W3022402577 cites W2939356024 @default.
- W3022402577 cites W2949677888 @default.
- W3022402577 cites W2951091094 @default.
- W3022402577 cites W2951348608 @default.
- W3022402577 cites W2962238782 @default.
- W3022402577 cites W3003551870 @default.
- W3022402577 cites W88342265 @default.
- W3022402577 doi "https://doi.org/10.1016/j.bbagrm.2020.194566" @default.
- W3022402577 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7350285" @default.
- W3022402577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32376391" @default.
- W3022402577 hasPublicationYear "2020" @default.
- W3022402577 type Work @default.
- W3022402577 sameAs 3022402577 @default.
- W3022402577 citedByCount "11" @default.
- W3022402577 countsByYear W30224025772021 @default.
- W3022402577 countsByYear W30224025772022 @default.
- W3022402577 countsByYear W30224025772023 @default.
- W3022402577 crossrefType "journal-article" @default.
- W3022402577 hasAuthorship W3022402577A5001747398 @default.
- W3022402577 hasAuthorship W3022402577A5026136298 @default.
- W3022402577 hasAuthorship W3022402577A5038917104 @default.
- W3022402577 hasAuthorship W3022402577A5044070375 @default.
- W3022402577 hasAuthorship W3022402577A5046533914 @default.