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• W3022420348 abstract "Integrating the properties of membranes with biological catalysts such as cells or enzymes forms the basis of a membrane bioreactor, which is an important technology advancing rapidly around the world in both research and commercial applications. This chapter gives an account of hollow-fiber bioreactors with a biocatalyst inoculated into the shell and immobilized within the membrane matrix or in a thin layer at the membrane matrix-shell interface. The membrane layer is useful for immobilizing whole cells and bioactive molecules such as enzymes to produce a wide variety of chemicals and substances. The performance of a hollow-fiber or sheet bioreactor is determined by the momentum and mass transport rate of the key nutrients through the biocatalytic membrane layer. The operating conditions and physical properties of the membrane influence the performance of a bioreactor and the effectiveness of the reaction. The technological difficulties in using membrane bioreactors on an industrial level are related to the rate-limiting aspects and scale-up difficulties of this technology. A mathematical description of the transport processes is provided, which enables the prediction of concentration distributions of nutrients in the catalyst membrane layer. Mathematical equations are provided to predict the concentration distribution and the mass transfer rate through the biocatalyst membrane layer as well as the concentration variation in the lumen side of a capillary membrane, with special regard to the variable transport parameters due to the anisotropy of the membrane and/or cell colony in or around the membrane." @default.
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• W3022420348 date "2012-01-01" @default.
• W3022420348 modified "2023-09-23" @default.
• W3022420348 title "Membrane Bioreactor" @default.
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• W3022420348 doi "https://doi.org/10.1016/b978-0-12-416025-5.00009-0" @default.
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