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- W3022425462 abstract "It is widely believed that the pathogenesis of Alzheimer's disease (AD) is intimately, if not causatively, associated with the deposition of ∼4 kDa β-amyloid (Aβ) peptides in the cerebral cortex and hippocampus of affected individuals. Aβ peptides are liberated from transmembrane proteins, termed β-amyloid precursor proteins (APP), by the concerted action of β- and γ-secretase(s). Whereas the identity of β-secretase is no longer in question, the identity of γ-secretase, which is responsible for the intramembranous processing of APP, has never been more enigmatic. Considerable evidence has accrued to impugn the presenilins (PS) as the executioners of intramembranous processing of APP. Here, we summarize these observations and review recent evidence that argues against the prevailing hypothesis that PS function as γ-secretases." @default.
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- W3022425462 date "2001-11-01" @default.
- W3022425462 modified "2023-10-06" @default.
- W3022425462 title "γ-Secretase: never more enigmatic" @default.
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- W3022425462 doi "https://doi.org/10.1016/s0166-2236(01)00002-9" @default.
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