FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022445245> ?p ?o ?g. }

• W3022445245 endingPage "106008" @default.
• W3022445245 startingPage "106008" @default.
• W3022445245 abstract "Appropriate dosing of antibiotics is key in the treatment of bacterial infections to ensure clinical efficacy while avoiding toxic drug concentrations and minimizing emergence of resistance. As collection of sufficient clinical evidence is difficult for specific patient populations, infection types and pathogens, market authorization, dosing strategies and recommendations often rely on data obtained from in vitro and animal experiments. The aim of this review is to provide an overview of commonly used preclinical infection models, including their strengths and limitations. In vitro, static and dynamic time-kill experiments are the most frequently used methods for assessing pharmacokinetic/pharmacodynamic (PK/PD) associations. Limitations of in vitro models include the inability to account for the effects of the immune system, and uncertainties in clinically relevant bacterial concentrations, growth conditions and the implications of emerging resistant bacterial populations during experiments. Animal experiments, most commonly murine lung and thigh infections models, are considered a necessary link between in vitro data and the clinical situation. However, there are differences in pathophysiology, immunology, and PK between species. Mathematical modeling in which preclinical data are integrated with human population PK can facilitate translation of preclinical data to the patient's clinical situation. Moreover, PK/PD modeling and simulations can help in the design of clinical trials aiming to establish optimal dosing regimens to improve patient outcomes." @default.
• W3022445245 created "2020-05-13" @default.
• W3022445245 creator A5062824753 @default.
• W3022445245 creator A5069262777 @default.
• W3022445245 creator A5074482150 @default.
• W3022445245 creator A5086916848 @default.
• W3022445245 date "2020-08-01" @default.
• W3022445245 modified "2023-09-23" @default.
• W3022445245 title "How preclinical infection models help define antibiotic doses in the clinic" @default.
• W3022445245 cites W1982462000 @default.
• W3022445245 cites W2000741779 @default.
• W3022445245 cites W2046281708 @default.
• W3022445245 cites W2075537997 @default.
• W3022445245 cites W2079691262 @default.
• W3022445245 cites W2097842992 @default.
• W3022445245 cites W2099906363 @default.
• W3022445245 cites W2113717321 @default.
• W3022445245 cites W2129122463 @default.
• W3022445245 cites W2143682782 @default.
• W3022445245 cites W2145456994 @default.
• W3022445245 cites W2145484866 @default.
• W3022445245 cites W2150760368 @default.
• W3022445245 cites W2159640725 @default.
• W3022445245 cites W2169951238 @default.
• W3022445245 cites W2316564861 @default.
• W3022445245 cites W2550207834 @default.
• W3022445245 cites W2606797031 @default.
• W3022445245 cites W2765892182 @default.
• W3022445245 cites W2769118269 @default.
• W3022445245 cites W2796472927 @default.
• W3022445245 cites W2809467692 @default.
• W3022445245 cites W2885405322 @default.
• W3022445245 cites W2901070409 @default.
• W3022445245 cites W2919778958 @default.
• W3022445245 cites W3012145662 @default.
• W3022445245 cites W3013163145 @default.
• W3022445245 cites W4211108359 @default.
• W3022445245 cites W4239557815 @default.
• W3022445245 cites W64724868 @default.
• W3022445245 doi "https://doi.org/10.1016/j.ijantimicag.2020.106008" @default.
• W3022445245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32389722" @default.
• W3022445245 hasPublicationYear "2020" @default.
• W3022445245 type Work @default.
• W3022445245 sameAs 3022445245 @default.
• W3022445245 citedByCount "11" @default.
• W3022445245 countsByYear W30224452452021 @default.
• W3022445245 countsByYear W30224452452022 @default.
• W3022445245 countsByYear W30224452452023 @default.
• W3022445245 crossrefType "journal-article" @default.
• W3022445245 hasAuthorship W3022445245A5062824753 @default.
• W3022445245 hasAuthorship W3022445245A5069262777 @default.
• W3022445245 hasAuthorship W3022445245A5074482150 @default.
• W3022445245 hasAuthorship W3022445245A5086916848 @default.
• W3022445245 hasBestOaLocation W30224452451 @default.
• W3022445245 hasConcept C111113717 @default.
• W3022445245 hasConcept C112705442 @default.
• W3022445245 hasConcept C126322002 @default.
• W3022445245 hasConcept C177713679 @default.
• W3022445245 hasConcept C2777288759 @default.
• W3022445245 hasConcept C2780035454 @default.
• W3022445245 hasConcept C2908647359 @default.
• W3022445245 hasConcept C501593827 @default.
• W3022445245 hasConcept C535046627 @default.
• W3022445245 hasConcept C71924100 @default.
• W3022445245 hasConcept C86803240 @default.
• W3022445245 hasConcept C89423630 @default.
• W3022445245 hasConcept C98274493 @default.
• W3022445245 hasConcept C99454951 @default.
• W3022445245 hasConceptScore W3022445245C111113717 @default.
• W3022445245 hasConceptScore W3022445245C112705442 @default.
• W3022445245 hasConceptScore W3022445245C126322002 @default.
• W3022445245 hasConceptScore W3022445245C177713679 @default.
• W3022445245 hasConceptScore W3022445245C2777288759 @default.
• W3022445245 hasConceptScore W3022445245C2780035454 @default.
• W3022445245 hasConceptScore W3022445245C2908647359 @default.
• W3022445245 hasConceptScore W3022445245C501593827 @default.
• W3022445245 hasConceptScore W3022445245C535046627 @default.
• W3022445245 hasConceptScore W3022445245C71924100 @default.
• W3022445245 hasConceptScore W3022445245C86803240 @default.
• W3022445245 hasConceptScore W3022445245C89423630 @default.
• W3022445245 hasConceptScore W3022445245C98274493 @default.
• W3022445245 hasConceptScore W3022445245C99454951 @default.
• W3022445245 hasFunder F4320322581 @default.
• W3022445245 hasIssue "2" @default.
• W3022445245 hasLocation W30224452451 @default.
• W3022445245 hasLocation W30224452452 @default.
• W3022445245 hasLocation W30224452453 @default.
• W3022445245 hasOpenAccess W3022445245 @default.
• W3022445245 hasPrimaryLocation W30224452451 @default.
• W3022445245 hasRelatedWork W1978032370 @default.
• W3022445245 hasRelatedWork W1979757582 @default.
• W3022445245 hasRelatedWork W2021319218 @default.
• W3022445245 hasRelatedWork W2059327436 @default.
• W3022445245 hasRelatedWork W2254638634 @default.
• W3022445245 hasRelatedWork W2332367370 @default.
• W3022445245 hasRelatedWork W2400461952 @default.
• W3022445245 hasRelatedWork W3021369409 @default.
• W3022445245 hasRelatedWork W3174177415 @default.

• next