Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022448695> ?p ?o ?g. }
- W3022448695 abstract "Abstract Malaria represents a life-threatening disease caused by the obligate intra-erythrocytic protozoa of the Plasmodium genus, exerting a sinister global health burden and accounting for approximately 660,000 deaths annually. Additionally, 219 million new cases are reported each year, most of which result from the growing issue of artemisinin resistance shown by the Plasmodium parasite. Much of the research done for the purpose of development of therapeutics against malaria has traditionally been focused on Plasmodium falciparum , which is responsible for majority of the cases of mortality due to malaria, Plasmodium vivax is also known to contribute greatly towards the malaria relate morbidities particularly in vivax endemic areas. In this study, we have used two different computational approaches aimed at establishing newer concepts towards the development of advanced therapeutics against vivax malaria by targeting the surface antigen, merozoite surface protein-1 (MSP-1). In-silico approach involving computational siRNA designing against MSP-1 resulted in a total of four candidate siRNAs being rationally validated following corroboration with a plethora of algorithms. Additionally, molecular docking analysis unraveled a total of three anti-parasitic peptides. These peptides namely: AP02283, AP02285 and AP00101 were found to exhibit considerable binding affinity with MSP-1 of P.vivax , thus providing an apparent indication of their anti-malarial property and affirming their potency to be used as novel molecules for development of next generation anti-malarials. However, irrespective of the prospective magnitude of these in-silico findings, the results require extensive validation by further rigorous laboratory experiments involving both in-vitro and in-vivo approaches." @default.
- W3022448695 created "2020-05-13" @default.
- W3022448695 creator A5004619720 @default.
- W3022448695 creator A5011924977 @default.
- W3022448695 creator A5017211800 @default.
- W3022448695 creator A5031641594 @default.
- W3022448695 creator A5040559704 @default.
- W3022448695 creator A5048723336 @default.
- W3022448695 creator A5058993969 @default.
- W3022448695 date "2020-05-03" @default.
- W3022448695 modified "2023-09-23" @default.
- W3022448695 title "An extensive computational approach to inhibit MSP-1 of P.vivax elucidates further horizon in the establishment next generation therapeutics against malaria" @default.
- W3022448695 cites W1487871178 @default.
- W3022448695 cites W1489256748 @default.
- W3022448695 cites W1542774706 @default.
- W3022448695 cites W1622422817 @default.
- W3022448695 cites W1839670086 @default.
- W3022448695 cites W1964146045 @default.
- W3022448695 cites W1971421983 @default.
- W3022448695 cites W1972746775 @default.
- W3022448695 cites W1973043023 @default.
- W3022448695 cites W1975806245 @default.
- W3022448695 cites W1984760454 @default.
- W3022448695 cites W1986159395 @default.
- W3022448695 cites W1990395260 @default.
- W3022448695 cites W1994616010 @default.
- W3022448695 cites W1994958179 @default.
- W3022448695 cites W2000438593 @default.
- W3022448695 cites W2009941225 @default.
- W3022448695 cites W2010484914 @default.
- W3022448695 cites W2012625502 @default.
- W3022448695 cites W2027954222 @default.
- W3022448695 cites W2029938306 @default.
- W3022448695 cites W2036287340 @default.
- W3022448695 cites W2039746015 @default.
- W3022448695 cites W2068942685 @default.
- W3022448695 cites W2083398732 @default.
- W3022448695 cites W2087458465 @default.
- W3022448695 cites W2088832194 @default.
- W3022448695 cites W2088998577 @default.
- W3022448695 cites W2093198351 @default.
- W3022448695 cites W2096155112 @default.
- W3022448695 cites W2096425628 @default.
- W3022448695 cites W2097874743 @default.
- W3022448695 cites W2099500226 @default.
- W3022448695 cites W2101386484 @default.
- W3022448695 cites W2102023232 @default.
- W3022448695 cites W2105668062 @default.
- W3022448695 cites W2110385304 @default.
- W3022448695 cites W2110574412 @default.
- W3022448695 cites W2115323998 @default.
- W3022448695 cites W2116009187 @default.
- W3022448695 cites W2119009518 @default.
- W3022448695 cites W2119340328 @default.
- W3022448695 cites W2123352893 @default.
- W3022448695 cites W2128341071 @default.
- W3022448695 cites W2129706781 @default.
- W3022448695 cites W2134054893 @default.
- W3022448695 cites W2137862593 @default.
- W3022448695 cites W2140818786 @default.
- W3022448695 cites W2141157874 @default.
- W3022448695 cites W2142768277 @default.
- W3022448695 cites W2143397050 @default.
- W3022448695 cites W2152519357 @default.
- W3022448695 cites W2152770371 @default.
- W3022448695 cites W2152981092 @default.
- W3022448695 cites W2153375634 @default.
- W3022448695 cites W2154241726 @default.
- W3022448695 cites W2154516306 @default.
- W3022448695 cites W2156878523 @default.
- W3022448695 cites W2157890819 @default.
- W3022448695 cites W2160397907 @default.
- W3022448695 cites W2161872337 @default.
- W3022448695 cites W2162913513 @default.
- W3022448695 cites W2168138163 @default.
- W3022448695 cites W2170781554 @default.
- W3022448695 cites W2281240954 @default.
- W3022448695 cites W2572149375 @default.
- W3022448695 cites W2605218043 @default.
- W3022448695 cites W2062274977 @default.
- W3022448695 doi "https://doi.org/10.1101/2020.05.02.073973" @default.
- W3022448695 hasPublicationYear "2020" @default.
- W3022448695 type Work @default.
- W3022448695 sameAs 3022448695 @default.
- W3022448695 citedByCount "0" @default.
- W3022448695 crossrefType "posted-content" @default.
- W3022448695 hasAuthorship W3022448695A5004619720 @default.
- W3022448695 hasAuthorship W3022448695A5011924977 @default.
- W3022448695 hasAuthorship W3022448695A5017211800 @default.
- W3022448695 hasAuthorship W3022448695A5031641594 @default.
- W3022448695 hasAuthorship W3022448695A5040559704 @default.
- W3022448695 hasAuthorship W3022448695A5048723336 @default.
- W3022448695 hasAuthorship W3022448695A5058993969 @default.
- W3022448695 hasBestOaLocation W30224486951 @default.
- W3022448695 hasConcept C104317684 @default.
- W3022448695 hasConcept C136764020 @default.
- W3022448695 hasConcept C142724271 @default.
- W3022448695 hasConcept C159047783 @default.
- W3022448695 hasConcept C203014093 @default.
- W3022448695 hasConcept C2775905019 @default.