Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022454080> ?p ?o ?g. }
- W3022454080 abstract "Abstract Hedgehog (Hh) signaling plays a broad role in the development of many organs including bone and teeth. It is noted that sustained Hh activity in osteoblasts negatively regulates postnatal development in mice. However, it remains unknown whether Hh signaling contributes to cementum formation. In this study, to define the roles of Hh signaling in cementum formation, we analyzed two kinds of transgenic mouse models for Hh signaling activation designed by the inactivation of Suppressor of Fused ( Sufu ), a negative regulator of Hh signaling, ( Sufu OC ) and a forced endogenous activation of Smo ( SmoM2 OC ) under the control of osteocalcin ( OC ) promoter-driven Cre recombinase. Interestingly, cellular cementum apposition was remarkably reduced in both mutants. Consistently, matrix formation and mineralization ability were down-regulated in OCCM-30, a cementoblast cell line, following treatment with a pharmaceutical Smo agonist. In addition, reductions in Osx expression and β-catenin activity, which are critical for cellular cementum formation, were also detected in vitro . Furthermore, the compound mutant mice designed for the stabilization of β-catenin with both Hh-Smo signaling activation in cementoblasts revealed a complete restoration of defective cellular cementum. In addition, Wnt antagonists such as Sostdc1 and Dkk1 were also induced by Smo activation and played a role in the reduction of Osx expression and β-catenin activity. Collectively, our data demonstrated that Hh signaling negatively regulates cementum apposition in a Wnt/β-catenin/Osx-dependent manner." @default.
- W3022454080 created "2020-05-13" @default.
- W3022454080 creator A5024164916 @default.
- W3022454080 creator A5046659345 @default.
- W3022454080 creator A5065732680 @default.
- W3022454080 creator A5079115940 @default.
- W3022454080 date "2020-04-29" @default.
- W3022454080 modified "2023-10-16" @default.
- W3022454080 title "Suppression of Hedgehog signaling is required for cementum apposition" @default.
- W3022454080 cites W1925759993 @default.
- W3022454080 cites W1980575724 @default.
- W3022454080 cites W2028212683 @default.
- W3022454080 cites W2035548935 @default.
- W3022454080 cites W2046762879 @default.
- W3022454080 cites W2048666625 @default.
- W3022454080 cites W2062275948 @default.
- W3022454080 cites W2073002574 @default.
- W3022454080 cites W2075738558 @default.
- W3022454080 cites W2087535559 @default.
- W3022454080 cites W2090863421 @default.
- W3022454080 cites W2097803027 @default.
- W3022454080 cites W2104370230 @default.
- W3022454080 cites W2108707301 @default.
- W3022454080 cites W2114712805 @default.
- W3022454080 cites W2114824375 @default.
- W3022454080 cites W2122367477 @default.
- W3022454080 cites W2125854041 @default.
- W3022454080 cites W2130034708 @default.
- W3022454080 cites W2132150825 @default.
- W3022454080 cites W2134438979 @default.
- W3022454080 cites W2158021558 @default.
- W3022454080 cites W2160889747 @default.
- W3022454080 cites W2164642954 @default.
- W3022454080 cites W2168132477 @default.
- W3022454080 cites W2168708923 @default.
- W3022454080 cites W2468215656 @default.
- W3022454080 cites W2743811642 @default.
- W3022454080 cites W2745034798 @default.
- W3022454080 cites W2943354371 @default.
- W3022454080 doi "https://doi.org/10.1038/s41598-020-64188-w" @default.
- W3022454080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7190817" @default.
- W3022454080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32350360" @default.
- W3022454080 hasPublicationYear "2020" @default.
- W3022454080 type Work @default.
- W3022454080 sameAs 3022454080 @default.
- W3022454080 citedByCount "6" @default.
- W3022454080 countsByYear W30224540802021 @default.
- W3022454080 countsByYear W30224540802022 @default.
- W3022454080 countsByYear W30224540802023 @default.
- W3022454080 crossrefType "journal-article" @default.
- W3022454080 hasAuthorship W3022454080A5024164916 @default.
- W3022454080 hasAuthorship W3022454080A5046659345 @default.
- W3022454080 hasAuthorship W3022454080A5065732680 @default.
- W3022454080 hasAuthorship W3022454080A5079115940 @default.
- W3022454080 hasBestOaLocation W30224540801 @default.
- W3022454080 hasConcept C137620995 @default.
- W3022454080 hasConcept C142724271 @default.
- W3022454080 hasConcept C185592680 @default.
- W3022454080 hasConcept C194529094 @default.
- W3022454080 hasConcept C2777894202 @default.
- W3022454080 hasConcept C2778539099 @default.
- W3022454080 hasConcept C2779263046 @default.
- W3022454080 hasConcept C2908931166 @default.
- W3022454080 hasConcept C56302369 @default.
- W3022454080 hasConcept C62478195 @default.
- W3022454080 hasConcept C71924100 @default.
- W3022454080 hasConcept C86803240 @default.
- W3022454080 hasConcept C88498014 @default.
- W3022454080 hasConcept C95444343 @default.
- W3022454080 hasConceptScore W3022454080C137620995 @default.
- W3022454080 hasConceptScore W3022454080C142724271 @default.
- W3022454080 hasConceptScore W3022454080C185592680 @default.
- W3022454080 hasConceptScore W3022454080C194529094 @default.
- W3022454080 hasConceptScore W3022454080C2777894202 @default.
- W3022454080 hasConceptScore W3022454080C2778539099 @default.
- W3022454080 hasConceptScore W3022454080C2779263046 @default.
- W3022454080 hasConceptScore W3022454080C2908931166 @default.
- W3022454080 hasConceptScore W3022454080C56302369 @default.
- W3022454080 hasConceptScore W3022454080C62478195 @default.
- W3022454080 hasConceptScore W3022454080C71924100 @default.
- W3022454080 hasConceptScore W3022454080C86803240 @default.
- W3022454080 hasConceptScore W3022454080C88498014 @default.
- W3022454080 hasConceptScore W3022454080C95444343 @default.
- W3022454080 hasFunder F4320322120 @default.
- W3022454080 hasIssue "1" @default.
- W3022454080 hasLocation W30224540801 @default.
- W3022454080 hasLocation W30224540802 @default.
- W3022454080 hasOpenAccess W3022454080 @default.
- W3022454080 hasPrimaryLocation W30224540801 @default.
- W3022454080 hasRelatedWork W1979843087 @default.
- W3022454080 hasRelatedWork W2046762879 @default.
- W3022454080 hasRelatedWork W2087535559 @default.
- W3022454080 hasRelatedWork W2119987653 @default.
- W3022454080 hasRelatedWork W2155480894 @default.
- W3022454080 hasRelatedWork W2194461569 @default.
- W3022454080 hasRelatedWork W2392136828 @default.
- W3022454080 hasRelatedWork W2400838482 @default.
- W3022454080 hasRelatedWork W3022454080 @default.
- W3022454080 hasRelatedWork W3146998500 @default.
- W3022454080 hasVolume "10" @default.