Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022461610> ?p ?o ?g. }
- W3022461610 endingPage "101135" @default.
- W3022461610 startingPage "101135" @default.
- W3022461610 abstract "Macrophages release a variety of extracellular vesicles (EVs). Here we describe a previously unreported class of EVs that are released from macrophages in response to Escherichia coli endotoxin, lipopolysaccharide (LPS), that we have named macrolets since they are extruded as large droplets released from macrophages. Morphologically, macrolets are anuclear, bounded by a single lipid membrane and structurally dependent on an actin cytoskeleton. Macrolets are enriched in tetraspanins and separable on this basis from their parent macrophages. Macrolets are distinguished from classic exosomes by their larger size (10–30 μm), discoid shape, and the presence of organelles. Macrolets are rich in both interleukin 6 (IL-6) and interleukin 6 receptor (IL-6R),and are capable of trapping and killing E. coli in association with production of reactive oxygen species. Our observations offer insights into the mechanisms by which macrophage activities may be amplified in sites of infection, inflammation, and healing." @default.
- W3022461610 created "2020-05-13" @default.
- W3022461610 creator A5013075366 @default.
- W3022461610 creator A5053198596 @default.
- W3022461610 creator A5057978103 @default.
- W3022461610 creator A5072419689 @default.
- W3022461610 date "2020-06-01" @default.
- W3022461610 modified "2023-09-27" @default.
- W3022461610 title "Macrolets: Outsized Extracellular Vesicles Released from Lipopolysaccharide-Stimulated Macrophages that Trap and Kill Escherichia coli" @default.
- W3022461610 cites W1541214776 @default.
- W3022461610 cites W1832266951 @default.
- W3022461610 cites W1861790843 @default.
- W3022461610 cites W1968558772 @default.
- W3022461610 cites W1969863654 @default.
- W3022461610 cites W1977323533 @default.
- W3022461610 cites W1985970823 @default.
- W3022461610 cites W1986820887 @default.
- W3022461610 cites W1990597414 @default.
- W3022461610 cites W1996649087 @default.
- W3022461610 cites W2019604250 @default.
- W3022461610 cites W2024341936 @default.
- W3022461610 cites W2030193400 @default.
- W3022461610 cites W2032639324 @default.
- W3022461610 cites W2038236600 @default.
- W3022461610 cites W2038363115 @default.
- W3022461610 cites W2040481506 @default.
- W3022461610 cites W2055620105 @default.
- W3022461610 cites W2062835892 @default.
- W3022461610 cites W2071871091 @default.
- W3022461610 cites W2091651178 @default.
- W3022461610 cites W2099008734 @default.
- W3022461610 cites W2101434902 @default.
- W3022461610 cites W2102202748 @default.
- W3022461610 cites W2131895213 @default.
- W3022461610 cites W2135756073 @default.
- W3022461610 cites W2140398331 @default.
- W3022461610 cites W2158070898 @default.
- W3022461610 cites W2162462917 @default.
- W3022461610 cites W2237743540 @default.
- W3022461610 cites W2259481044 @default.
- W3022461610 cites W2331647907 @default.
- W3022461610 cites W2401460918 @default.
- W3022461610 cites W2441633445 @default.
- W3022461610 cites W2533823643 @default.
- W3022461610 cites W2565849713 @default.
- W3022461610 cites W2579756956 @default.
- W3022461610 cites W2591817253 @default.
- W3022461610 cites W2592843746 @default.
- W3022461610 cites W2593091324 @default.
- W3022461610 cites W2621787899 @default.
- W3022461610 cites W2737388023 @default.
- W3022461610 cites W2752260686 @default.
- W3022461610 cites W2763973319 @default.
- W3022461610 cites W2766435905 @default.
- W3022461610 cites W2769917750 @default.
- W3022461610 cites W2783733036 @default.
- W3022461610 cites W2807747736 @default.
- W3022461610 cites W2887329987 @default.
- W3022461610 cites W2896975388 @default.
- W3022461610 cites W2900756811 @default.
- W3022461610 cites W2904582173 @default.
- W3022461610 cites W2921678390 @default.
- W3022461610 cites W2966435370 @default.
- W3022461610 doi "https://doi.org/10.1016/j.isci.2020.101135" @default.
- W3022461610 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7240733" @default.
- W3022461610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32442747" @default.
- W3022461610 hasPublicationYear "2020" @default.
- W3022461610 type Work @default.
- W3022461610 sameAs 3022461610 @default.
- W3022461610 citedByCount "5" @default.
- W3022461610 countsByYear W30224616102020 @default.
- W3022461610 countsByYear W30224616102021 @default.
- W3022461610 countsByYear W30224616102023 @default.
- W3022461610 crossrefType "journal-article" @default.
- W3022461610 hasAuthorship W3022461610A5013075366 @default.
- W3022461610 hasAuthorship W3022461610A5053198596 @default.
- W3022461610 hasAuthorship W3022461610A5057978103 @default.
- W3022461610 hasAuthorship W3022461610A5072419689 @default.
- W3022461610 hasBestOaLocation W30224616101 @default.
- W3022461610 hasConcept C104317684 @default.
- W3022461610 hasConcept C125705527 @default.
- W3022461610 hasConcept C130316041 @default.
- W3022461610 hasConcept C134897094 @default.
- W3022461610 hasConcept C142669718 @default.
- W3022461610 hasConcept C145059251 @default.
- W3022461610 hasConcept C1491633281 @default.
- W3022461610 hasConcept C168240541 @default.
- W3022461610 hasConcept C17991360 @default.
- W3022461610 hasConcept C185592680 @default.
- W3022461610 hasConcept C202751555 @default.
- W3022461610 hasConcept C203014093 @default.
- W3022461610 hasConcept C20518536 @default.
- W3022461610 hasConcept C2776914184 @default.
- W3022461610 hasConcept C2778754761 @default.
- W3022461610 hasConcept C2779244956 @default.
- W3022461610 hasConcept C28406088 @default.
- W3022461610 hasConcept C41625074 @default.
- W3022461610 hasConcept C547475151 @default.