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• W3022479802 abstract "Adverse drug reactions (ADRs) are a major problem in clinical practice and drug development. Estimates suggest that they represent 6.5–6.7% of acute hospital admissions. ADRs represent the most common reason for drug withdrawal and the failure of new drugs to reach the market. They are commonly classified as type A (augmented) or type B (bizarre). Type A ADRs are predictable from the known pharmacology of the drug, and research has focused on genetic variation in drug metabolism pathways, such as cytochrome P450 enzymes, to explain the variation in ADR susceptibility. Success with this approach has been highlighted by the tailoring of azathioprine dosages according to thiopurine S-methyltransferase status. Type B ADRs are not predictable from the known pharmacology of the drug and include hypersensitivity reactions to antiepileptics and statin-induced myopathy. Several strong human leukocyte antigen (HLA) associations have been reported for type B ADRs, and testing for human leukocyte antigen B*57:01 is now routine prior to abacavir therapy. This chapter reviews the reported genetic associations with ADRs and explains their significance in clinical practice and the barriers to their clinical implementation." @default.
• W3022479802 created "2020-05-13" @default.
• W3022479802 creator A5006847944 @default.
• W3022479802 creator A5072175945 @default.
• W3022479802 creator A5080742306 @default.
• W3022479802 date "2014-01-01" @default.
• W3022479802 modified "2023-10-12" @default.
• W3022479802 title "Adverse Drug Reactions" @default.
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