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- W3022521845 endingPage "177" @default.
- W3022521845 startingPage "139" @default.
- W3022521845 abstract "Mitochondria play key roles in numerous cellular processes, including ATP production, calcium homeostasis, and cell death pathways. In no cell type is their function more vital than in long-lived neurons, where mitochondria must be maintained for an entire lifetime, and where energy requirements are very high and long axons necessitate energy transport over large distances. While functioning mitochondria are key for maintaining cellular health, dysfunctional mitochondria can generate excessive amounts of reactive oxygen species that contribute to oxidative damage in a range of neurodegenerative diseases, including Parkinson’s disease (PD). It is therefore essential for the heavily damaged mitochondria to be removed to avoid their toxic accumulation. This occurs through a selective autophagic process, called mitophagy. The majority of what we know about mitophagy originates from the PD-associated genes PINK1 and Parkin, with research over the past 10 years shedding light on the molecular mechanisms of the process. In this chapter, we describe the mitophagy model and how it evolved in the last few years. We discuss the methodologies currently available to measure mitophagy, and we reflect on the outstanding questions that remain to be answered in order to further understand mitophagy and be able to target the process to treat or prevent PD." @default.
- W3022521845 created "2020-05-13" @default.
- W3022521845 creator A5037187338 @default.
- W3022521845 creator A5045997682 @default.
- W3022521845 date "2017-01-01" @default.
- W3022521845 modified "2023-10-16" @default.
- W3022521845 title "Mitophagy" @default.
- W3022521845 cites W1003328989 @default.
- W3022521845 cites W1507318381 @default.
- W3022521845 cites W1510443235 @default.
- W3022521845 cites W1518704304 @default.
- W3022521845 cites W1550876205 @default.
- W3022521845 cites W1555401845 @default.
- W3022521845 cites W1727383321 @default.
- W3022521845 cites W1770535374 @default.
- W3022521845 cites W1821174618 @default.
- W3022521845 cites W1844043090 @default.
- W3022521845 cites W1877873625 @default.
- W3022521845 cites W1884950180 @default.
- W3022521845 cites W1932694010 @default.
- W3022521845 cites W1941635000 @default.
- W3022521845 cites W1965641455 @default.
- W3022521845 cites W1967646152 @default.
- W3022521845 cites W1968347386 @default.
- W3022521845 cites W1968364090 @default.
- W3022521845 cites W1968698003 @default.
- W3022521845 cites W1969300701 @default.
- W3022521845 cites W1969800514 @default.
- W3022521845 cites W1973926398 @default.
- W3022521845 cites W1975594363 @default.
- W3022521845 cites W1975927237 @default.
- W3022521845 cites W1979462186 @default.
- W3022521845 cites W1979645469 @default.
- W3022521845 cites W1981727895 @default.
- W3022521845 cites W1982861224 @default.
- W3022521845 cites W1985119207 @default.
- W3022521845 cites W1986033053 @default.
- W3022521845 cites W1986188355 @default.
- W3022521845 cites W1989026904 @default.
- W3022521845 cites W1989293830 @default.
- W3022521845 cites W1990048226 @default.
- W3022521845 cites W1990287702 @default.
- W3022521845 cites W1990496517 @default.
- W3022521845 cites W1991105254 @default.
- W3022521845 cites W1992264711 @default.
- W3022521845 cites W1992947862 @default.
- W3022521845 cites W1993098682 @default.
- W3022521845 cites W1993479669 @default.
- W3022521845 cites W1993733276 @default.
- W3022521845 cites W1993772997 @default.
- W3022521845 cites W1995700909 @default.
- W3022521845 cites W1996625702 @default.
- W3022521845 cites W1999059411 @default.
- W3022521845 cites W2000802512 @default.
- W3022521845 cites W2001977333 @default.
- W3022521845 cites W2001993306 @default.
- W3022521845 cites W2003251187 @default.
- W3022521845 cites W2004908477 @default.
- W3022521845 cites W2006685379 @default.
- W3022521845 cites W2007301017 @default.
- W3022521845 cites W2007997420 @default.
- W3022521845 cites W2009321462 @default.
- W3022521845 cites W2009503896 @default.
- W3022521845 cites W2009734791 @default.
- W3022521845 cites W2010457089 @default.
- W3022521845 cites W2011124366 @default.
- W3022521845 cites W2011894009 @default.
- W3022521845 cites W2013961803 @default.
- W3022521845 cites W2014459126 @default.
- W3022521845 cites W2015116743 @default.
- W3022521845 cites W2017028262 @default.
- W3022521845 cites W2017056204 @default.
- W3022521845 cites W2018133355 @default.
- W3022521845 cites W2019443416 @default.
- W3022521845 cites W2021528199 @default.
- W3022521845 cites W2024610036 @default.
- W3022521845 cites W2025060864 @default.
- W3022521845 cites W2025521110 @default.
- W3022521845 cites W2025872915 @default.
- W3022521845 cites W2026169768 @default.
- W3022521845 cites W2026540198 @default.
- W3022521845 cites W2027566683 @default.
- W3022521845 cites W2028267102 @default.
- W3022521845 cites W2031305815 @default.
- W3022521845 cites W2033766052 @default.
- W3022521845 cites W2033832481 @default.
- W3022521845 cites W2034087770 @default.
- W3022521845 cites W2035799305 @default.
- W3022521845 cites W2037008545 @default.
- W3022521845 cites W2037316279 @default.
- W3022521845 cites W2037487430 @default.
- W3022521845 cites W2037967087 @default.
- W3022521845 cites W2038346519 @default.
- W3022521845 cites W2038834667 @default.
- W3022521845 cites W2038976751 @default.
- W3022521845 cites W2039276829 @default.
- W3022521845 cites W2039489702 @default.
- W3022521845 cites W2042396829 @default.