FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022579279> ?p ?o ?g. }

• W3022579279 endingPage "419" @default.
• W3022579279 startingPage "413" @default.
• W3022579279 abstract "ObjectivesCefazolin is one of curative treatments for infections due to methicillin-sensitive Staphylococcus aureus (MSSA). Both growth and critical illness may impact the pharmacokinetic (PK) parameters. We aimed to build a population PK model for cefazolin in critically ill children in order to optimize individual dosing regimens.MethodsWe included all children (age < 18 years, body weight (BW) > 2.5 kg) receiving cefazolin for MSSA infection. Cefazolin total plasma concentrations were quantified by high-performance liquid chromatography. A data modelling process was performed with the software MONOLIX. Monte Carlo simulations were used in order to attain the PK target of 100% fT > 4 × MIC.ResultsThirty-nine patients with a median (range) age of 7 (0.1–17) years and a BW of 21 (2.8–79) kg were included. The PK was ascribed to a one-compartment model, where typical clearance and volume of distribution estimations were 1.4 L/h and 3.3 L respectively. BW, according to the allometric rules, and estimated glomerular filtration rate (eGFR) on clearance were the two influential covariates. Continuous infusion with a dosing of 100 mg/kg/day to increase to 150 mg/kg/day for children with a BW < 10 kg or eGFR >200 mL/min/1.73m2 were the best schemes to reach the PK target of 100% fT > 4 × MIC.ConclusionsIn critically ill children infected with MSSA, continuous infusion seems to be the most appropriate scheme to reach the PK target of 100 % fT > 4 × MIC in children with normal and augmented renal function." @default.
• W3022579279 created "2020-05-13" @default.
• W3022579279 creator A5007305475 @default.
• W3022579279 creator A5013183591 @default.
• W3022579279 creator A5021818608 @default.
• W3022579279 creator A5022450468 @default.
• W3022579279 creator A5036305862 @default.
• W3022579279 creator A5036481508 @default.
• W3022579279 creator A5037089281 @default.
• W3022579279 creator A5037696502 @default.
• W3022579279 creator A5051466553 @default.
• W3022579279 creator A5052748416 @default.
• W3022579279 creator A5053569973 @default.
• W3022579279 creator A5057401398 @default.
• W3022579279 creator A5063984069 @default.
• W3022579279 creator A5067533311 @default.
• W3022579279 creator A5069523229 @default.
• W3022579279 creator A5071061744 @default.
• W3022579279 creator A5083133102 @default.
• W3022579279 date "2021-03-01" @default.
• W3022579279 modified "2023-10-14" @default.
• W3022579279 title "Population pharmacokinetics of cefazolin in critically ill children infected with methicillin-sensitive Staphylococcus aureus" @default.
• W3022579279 cites W1960255425 @default.
• W3022579279 cites W1989205263 @default.
• W3022579279 cites W2042553471 @default.
• W3022579279 cites W2076590961 @default.
• W3022579279 cites W2084074709 @default.
• W3022579279 cites W2085150747 @default.
• W3022579279 cites W2093073135 @default.
• W3022579279 cites W2119289429 @default.
• W3022579279 cites W2120416054 @default.
• W3022579279 cites W2123960693 @default.
• W3022579279 cites W2133979383 @default.
• W3022579279 cites W2149974939 @default.
• W3022579279 cites W2166356134 @default.
• W3022579279 cites W2167943565 @default.
• W3022579279 cites W2321829810 @default.
• W3022579279 cites W2337603947 @default.
• W3022579279 cites W2424861957 @default.
• W3022579279 cites W2511781930 @default.
• W3022579279 cites W2564865657 @default.
• W3022579279 cites W2588163058 @default.
• W3022579279 cites W2740977860 @default.
• W3022579279 cites W2889049942 @default.
• W3022579279 cites W2898129585 @default.
• W3022579279 cites W2911942018 @default.
• W3022579279 cites W2917216592 @default.
• W3022579279 cites W2929478224 @default.
• W3022579279 cites W2929590973 @default.
• W3022579279 cites W2929812674 @default.
• W3022579279 cites W4247934261 @default.
• W3022579279 doi "https://doi.org/10.1016/j.cmi.2020.04.022" @default.
• W3022579279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32360445" @default.
• W3022579279 hasPublicationYear "2021" @default.
• W3022579279 type Work @default.
• W3022579279 sameAs 3022579279 @default.
• W3022579279 citedByCount "6" @default.
• W3022579279 countsByYear W30225792792021 @default.
• W3022579279 countsByYear W30225792792022 @default.
• W3022579279 countsByYear W30225792792023 @default.
• W3022579279 crossrefType "journal-article" @default.
• W3022579279 hasAuthorship W3022579279A5007305475 @default.
• W3022579279 hasAuthorship W3022579279A5013183591 @default.
• W3022579279 hasAuthorship W3022579279A5021818608 @default.
• W3022579279 hasAuthorship W3022579279A5022450468 @default.
• W3022579279 hasAuthorship W3022579279A5036305862 @default.
• W3022579279 hasAuthorship W3022579279A5036481508 @default.
• W3022579279 hasAuthorship W3022579279A5037089281 @default.
• W3022579279 hasAuthorship W3022579279A5037696502 @default.
• W3022579279 hasAuthorship W3022579279A5051466553 @default.
• W3022579279 hasAuthorship W3022579279A5052748416 @default.
• W3022579279 hasAuthorship W3022579279A5053569973 @default.
• W3022579279 hasAuthorship W3022579279A5057401398 @default.
• W3022579279 hasAuthorship W3022579279A5063984069 @default.
• W3022579279 hasAuthorship W3022579279A5067533311 @default.
• W3022579279 hasAuthorship W3022579279A5069523229 @default.
• W3022579279 hasAuthorship W3022579279A5071061744 @default.
• W3022579279 hasAuthorship W3022579279A5083133102 @default.
• W3022579279 hasBestOaLocation W30225792791 @default.
• W3022579279 hasConcept C112705442 @default.
• W3022579279 hasConcept C126322002 @default.
• W3022579279 hasConcept C126894567 @default.
• W3022579279 hasConcept C139254425 @default.
• W3022579279 hasConcept C159641895 @default.
• W3022579279 hasConcept C2777288759 @default.
• W3022579279 hasConcept C2778353156 @default.
• W3022579279 hasConcept C2779489039 @default.
• W3022579279 hasConcept C2908647359 @default.
• W3022579279 hasConcept C3020755252 @default.
• W3022579279 hasConcept C42219234 @default.
• W3022579279 hasConcept C501593827 @default.
• W3022579279 hasConcept C523546767 @default.
• W3022579279 hasConcept C54355233 @default.
• W3022579279 hasConcept C71924100 @default.
• W3022579279 hasConcept C86803240 @default.
• W3022579279 hasConcept C89423630 @default.
• W3022579279 hasConcept C99454951 @default.
• W3022579279 hasConceptScore W3022579279C112705442 @default.

• next