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- W3022584349 abstract "Validate that we can effectively deliver radiation to a confined region of the mouse brain as evidenced by comparison of pre and post-irradiation, in-vivo MR images. Two NCR athymic nude mice were focally irradiated with 15 beams spaced equally over 210° in the coronal plane to single-fraction maximum doses of 22 and 33 Gy (±10%). The x-ray source position remained fixed while the prone mice were rotated on a movable stage. A constant-voltage source provided 225 kVp x rays, while a 0.75 mm beam aperture defined a 1.5 mm (FWHM) circular radiation field at the treatment isocenter. T2-weighted micro MR scans were acquired both pre and 20 hours post-irradiation with an 11.7 Tesla NMR spectrometer (Bruker Biospin, Billerica, MA, USA) using a fast spin-echo sequence. The total imaging time required was 45 minutes per mouse, per session. Figure 1 shows three orthogonal cuts through the volume for one of the mice prior to treatment. CT treatment simulation and dose planning was used prior to treatment to accurately localize the right frontal lobe region of each mouse brain and determine the effective depth to be used for the dose calculations. Figure 2 shows the CT-based dose distribution and brain DVH for the mouse that received 33 Gy using our preliminary Pinnacle (ADAC/Philips) Monte Carlo model. These data are satisfying in that they closely mimic clinically-based radiation planning and treatment delivery to the human brain. The time between irradiation and the post-treatment MR proved to be insufficient, as no changes were observed qualitatively comparing the sets of images for each mouse. We anticipate that later MR follow-up imaging will show localized contrast differences; we endeavor to extend this investigation. We gratefully acknowledge Dr. Susumu Mori from the Department of Radiology for providing the MR capabilities demonstrated here. This work has been supported in part by grant NCI R01–108449." @default.
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- W3022584349 date "2006-11-01" @default.
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- W3022584349 title "2635" @default.
- W3022584349 doi "https://doi.org/10.1016/j.ijrobp.2006.07.1049" @default.
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