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- W3022605211 abstract "Since its discovery 25 years ago by our group and Grabstein et al. [1–3], interleukin-15 (IL-15) has attracted much attention in terms of its biological activities, mechanism of action and therapeutic modulations under various physiological and pathological conditions. In particular, the stimulatory effects of IL-15 on the proliferation and effector functions of natural killer (NK) cells and CD8+ T cells make it a promising component for immunotherapy in the treatment of malignancies and infectious diseases [4,5]. Here, we present a brief summary on the biological principles of how IL-15 exerts immunostimulatory effects on cells, the clinical investigations on IL-15-based therapeutic agents, and the challenges for safe and efficacious delivery of IL-15 in patients." @default.
- W3022605211 created "2020-05-13" @default.
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- W3022605211 date "2020-05-19" @default.
- W3022605211 modified "2023-09-27" @default.
- W3022605211 title "Bench-to-bedside translation of interleukin-15 for immunotherapy: principles and challenges" @default.
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- W3022605211 doi "https://doi.org/10.1080/17425247.2020.1764933" @default.
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