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- W3022634557 abstract "Publisher SummaryEarly attempts at restoring the continuity of the divided peripheral nerve depended on as accurate as possible coaptation of the epineurium. As suggested by the foregoing anatomical details, malrotation, buckling, and a low nerve to connective tissue ratio provided a uniformly poor functional result. To minimize fibrosis and neuroma formation, various materials were introduced as barriers or tubes around the anastomosis. Tantalum shields stopped the ingrowth of fibrous tissue and gave improved structure and initial function but unfortunately fragmented giving rise to scar tissue and a secondary reduction of function. The late 19th century saw the introduction of grafts to bridge deficits in peripheral nerves. Phillipeaux and Vulpian (1870) demonstrated that nerve fibres would grow through a graft and shortly afterward, the first nerve homograft was used to bridge a 3 cm deficit in a median nerve. Immunological rejection has plagued the use of homografts ever since, although the use of irradiated homografts was considered a feasible method of bridging a nerve defect." @default.
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- W3022634557 date "1984-01-01" @default.
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- W3022634557 title "Nerve repair" @default.
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- W3022634557 doi "https://doi.org/10.1016/b978-0-407-00308-8.50057-4" @default.
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