Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022644595> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W3022644595 abstract "We study a minimal model of the stress-driven p53 regulatory network that includes competition between active and mutant forms of the tumor-suppressor gene p53. Depending on the nature of the external stress signal, four distinct dynamical states are observed. These states can be distinguished by dierent dynamical properties and correspond to active, apoptotic, pre-malignant and cancer states. Transitions between any two of these states are found to be unidirectional and irreversible if the stress signal is either oscillatory or constant. When the signal decays exponentially, the apoptotic state vanishes, and for low stress the pre-malignant state is bounded by two critical points, allowing the system to transition reversibly from the active to the pre-malignant state. For signicantly large stress, the range of the pre-malignant state expands and the system moves to the cancerous state which is a stable attractor. This suggests that identification of the pre-malignant state may be important both for therapeutic intervention as well as for drug discovery." @default.
- W3022644595 created "2020-05-13" @default.
- W3022644595 creator A5025795847 @default.
- W3022644595 creator A5026145538 @default.
- W3022644595 creator A5058911791 @default.
- W3022644595 creator A5078315190 @default.
- W3022644595 date "2020-05-05" @default.
- W3022644595 modified "2023-09-30" @default.
- W3022644595 title "Cancer Dynamics: Identification of States for Therapeutic Intervention" @default.
- W3022644595 doi "https://doi.org/10.20944/preprints202005.0063.v1" @default.
- W3022644595 hasPublicationYear "2020" @default.
- W3022644595 type Work @default.
- W3022644595 sameAs 3022644595 @default.
- W3022644595 citedByCount "0" @default.
- W3022644595 crossrefType "posted-content" @default.
- W3022644595 hasAuthorship W3022644595A5025795847 @default.
- W3022644595 hasAuthorship W3022644595A5026145538 @default.
- W3022644595 hasAuthorship W3022644595A5058911791 @default.
- W3022644595 hasAuthorship W3022644595A5078315190 @default.
- W3022644595 hasBestOaLocation W30226445951 @default.
- W3022644595 hasConcept C104317684 @default.
- W3022644595 hasConcept C11413529 @default.
- W3022644595 hasConcept C116834253 @default.
- W3022644595 hasConcept C121332964 @default.
- W3022644595 hasConcept C121608353 @default.
- W3022644595 hasConcept C121864883 @default.
- W3022644595 hasConcept C134306372 @default.
- W3022644595 hasConcept C138885662 @default.
- W3022644595 hasConcept C143065580 @default.
- W3022644595 hasConcept C164380108 @default.
- W3022644595 hasConcept C179185449 @default.
- W3022644595 hasConcept C186060115 @default.
- W3022644595 hasConcept C199360897 @default.
- W3022644595 hasConcept C21036866 @default.
- W3022644595 hasConcept C2779843651 @default.
- W3022644595 hasConcept C33923547 @default.
- W3022644595 hasConcept C41008148 @default.
- W3022644595 hasConcept C41895202 @default.
- W3022644595 hasConcept C48103436 @default.
- W3022644595 hasConcept C502942594 @default.
- W3022644595 hasConcept C54355233 @default.
- W3022644595 hasConcept C59822182 @default.
- W3022644595 hasConcept C86803240 @default.
- W3022644595 hasConceptScore W3022644595C104317684 @default.
- W3022644595 hasConceptScore W3022644595C11413529 @default.
- W3022644595 hasConceptScore W3022644595C116834253 @default.
- W3022644595 hasConceptScore W3022644595C121332964 @default.
- W3022644595 hasConceptScore W3022644595C121608353 @default.
- W3022644595 hasConceptScore W3022644595C121864883 @default.
- W3022644595 hasConceptScore W3022644595C134306372 @default.
- W3022644595 hasConceptScore W3022644595C138885662 @default.
- W3022644595 hasConceptScore W3022644595C143065580 @default.
- W3022644595 hasConceptScore W3022644595C164380108 @default.
- W3022644595 hasConceptScore W3022644595C179185449 @default.
- W3022644595 hasConceptScore W3022644595C186060115 @default.
- W3022644595 hasConceptScore W3022644595C199360897 @default.
- W3022644595 hasConceptScore W3022644595C21036866 @default.
- W3022644595 hasConceptScore W3022644595C2779843651 @default.
- W3022644595 hasConceptScore W3022644595C33923547 @default.
- W3022644595 hasConceptScore W3022644595C41008148 @default.
- W3022644595 hasConceptScore W3022644595C41895202 @default.
- W3022644595 hasConceptScore W3022644595C48103436 @default.
- W3022644595 hasConceptScore W3022644595C502942594 @default.
- W3022644595 hasConceptScore W3022644595C54355233 @default.
- W3022644595 hasConceptScore W3022644595C59822182 @default.
- W3022644595 hasConceptScore W3022644595C86803240 @default.
- W3022644595 hasLocation W30226445951 @default.
- W3022644595 hasOpenAccess W3022644595 @default.
- W3022644595 hasPrimaryLocation W30226445951 @default.
- W3022644595 hasRelatedWork W10792125 @default.
- W3022644595 hasRelatedWork W11063172 @default.
- W3022644595 hasRelatedWork W13209649 @default.
- W3022644595 hasRelatedWork W15986361 @default.
- W3022644595 hasRelatedWork W15997403 @default.
- W3022644595 hasRelatedWork W19073991 @default.
- W3022644595 hasRelatedWork W20720157 @default.
- W3022644595 hasRelatedWork W2483517 @default.
- W3022644595 hasRelatedWork W2641805 @default.
- W3022644595 hasRelatedWork W2973904 @default.
- W3022644595 isParatext "false" @default.
- W3022644595 isRetracted "false" @default.
- W3022644595 magId "3022644595" @default.
- W3022644595 workType "article" @default.