FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022647551> ?p ?o ?g. }

• W3022647551 endingPage "191" @default.
• W3022647551 startingPage "175" @default.
• W3022647551 abstract "The present investigation sought to determine the neuroanatomical locus through which the amnesic and anxiolytic effects of the benzodiazepine agonist chlordiazepoxide are mediated. Rats were infused with either chlordiazepoxide (60 nmol/μl) or artificial CSF (1 μl) into either the frontal cortex, nucleus basalis magnocellularis/substantia innominata, amygdala, medial septum, hippocampus, or cerebellum and run in the open field to assess anxiety as thigmotaxia and in the Morris water maze to assess spatial learning. Other rats were given chlordiazepoxide (5 mg/kg) or saline (1 ml/kg) systemically and run in the open field and water maze. When chlordiazepoxide was administered systemically, rats showed significantly less thigmotaxia, but not overall activity, than controls in the open field, and were deficit in spatial learning, but not cue learning or swim speed, in the water maze. Intracranial infusions revealed a neuroanatomical specificity for the amnesic and anxiolytic actions of chlordiazepoxide. Infusions of chlordiazepoxide into the amygdala, but none of the other structures, reduced thigmotaxia without affecting overall activity levels whereas infusions into the medial septum, but none of the other structures, prevented spatial learning, but not cue learning, and reduced swim speed in the water maze. Together, these finding suggest that the medial septum and the amygdala mediate the amnesic and anxiolytic actions of chlordiazepoxide, respectively. Moreover, these results provide direct evidence that the amnesic and anxiolytic actions of chlordiazepoxide are independent." @default.
• W3022647551 created "2020-05-13" @default.
• W3022647551 creator A5061204435 @default.
• W3022647551 creator A5085429169 @default.
• W3022647551 date "1993-12-01" @default.
• W3022647551 modified "2023-10-15" @default.
• W3022647551 title "Effects of intracranial infusions of chlordiazepoxide on spatial learning in the Morris water maze. I. Neuroanatomical specificity" @default.
• W3022647551 cites W1968764682 @default.
• W3022647551 cites W1973285360 @default.
• W3022647551 cites W1976609539 @default.
• W3022647551 cites W1978803611 @default.
• W3022647551 cites W1981117745 @default.
• W3022647551 cites W1992975043 @default.
• W3022647551 cites W1994097311 @default.
• W3022647551 cites W1996372262 @default.
• W3022647551 cites W1996661732 @default.
• W3022647551 cites W2000154350 @default.
• W3022647551 cites W2008115103 @default.
• W3022647551 cites W2009912729 @default.
• W3022647551 cites W2010526028 @default.
• W3022647551 cites W2011349403 @default.
• W3022647551 cites W2015275360 @default.
• W3022647551 cites W2016175901 @default.
• W3022647551 cites W2016261700 @default.
• W3022647551 cites W2017169966 @default.
• W3022647551 cites W2018746730 @default.
• W3022647551 cites W2018761259 @default.
• W3022647551 cites W2019207602 @default.
• W3022647551 cites W2019842287 @default.
• W3022647551 cites W2020751425 @default.
• W3022647551 cites W2026512899 @default.
• W3022647551 cites W2030282216 @default.
• W3022647551 cites W2030607172 @default.
• W3022647551 cites W2033281125 @default.
• W3022647551 cites W2033367005 @default.
• W3022647551 cites W2033427356 @default.
• W3022647551 cites W2038476226 @default.
• W3022647551 cites W2039905869 @default.
• W3022647551 cites W2045621697 @default.
• W3022647551 cites W2045694402 @default.
• W3022647551 cites W2051328423 @default.
• W3022647551 cites W2057936308 @default.
• W3022647551 cites W2059508421 @default.
• W3022647551 cites W2067214792 @default.
• W3022647551 cites W2068279857 @default.
• W3022647551 cites W2069203742 @default.
• W3022647551 cites W2070066292 @default.
• W3022647551 cites W2071260447 @default.
• W3022647551 cites W2071492556 @default.
• W3022647551 cites W2072961137 @default.
• W3022647551 cites W2080937894 @default.
• W3022647551 cites W2084630676 @default.
• W3022647551 cites W2089379546 @default.
• W3022647551 cites W2089433009 @default.
• W3022647551 cites W2103140876 @default.
• W3022647551 cites W2153675071 @default.
• W3022647551 cites W2163006398 @default.
• W3022647551 cites W2169473035 @default.
• W3022647551 cites W4233354889 @default.
• W3022647551 cites W4241057057 @default.
• W3022647551 cites W4241138662 @default.
• W3022647551 doi "https://doi.org/10.1016/0166-4328(93)90165-m" @default.
• W3022647551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7908804" @default.
• W3022647551 hasPublicationYear "1993" @default.
• W3022647551 type Work @default.
• W3022647551 sameAs 3022647551 @default.
• W3022647551 citedByCount "50" @default.
• W3022647551 countsByYear W30226475512013 @default.
• W3022647551 countsByYear W30226475512014 @default.
• W3022647551 countsByYear W30226475512015 @default.
• W3022647551 crossrefType "journal-article" @default.
• W3022647551 hasAuthorship W3022647551A5061204435 @default.
• W3022647551 hasAuthorship W3022647551A5085429169 @default.
• W3022647551 hasConcept C118552586 @default.
• W3022647551 hasConcept C12515866 @default.
• W3022647551 hasConcept C126322002 @default.
• W3022647551 hasConcept C15744967 @default.
• W3022647551 hasConcept C169760540 @default.
• W3022647551 hasConcept C170493617 @default.
• W3022647551 hasConcept C173586616 @default.
• W3022647551 hasConcept C2776175493 @default.
• W3022647551 hasConcept C2777765862 @default.
• W3022647551 hasConcept C2778173252 @default.
• W3022647551 hasConcept C2778325228 @default.
• W3022647551 hasConcept C2779085643 @default.
• W3022647551 hasConcept C2779144063 @default.
• W3022647551 hasConcept C2781161787 @default.
• W3022647551 hasConcept C2910500303 @default.
• W3022647551 hasConcept C42219234 @default.
• W3022647551 hasConcept C44752575 @default.
• W3022647551 hasConcept C558461103 @default.
• W3022647551 hasConcept C71924100 @default.
• W3022647551 hasConceptScore W3022647551C118552586 @default.
• W3022647551 hasConceptScore W3022647551C12515866 @default.
• W3022647551 hasConceptScore W3022647551C126322002 @default.
• W3022647551 hasConceptScore W3022647551C15744967 @default.
• W3022647551 hasConceptScore W3022647551C169760540 @default.
• W3022647551 hasConceptScore W3022647551C170493617 @default.

• next